Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 60, Issue 2, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2022.5302
Keywords
tumour; immunotherapy; monoclonal antibody; phage display technology; A single B cell monoclonal antibody generation technology
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Funding
- National Natural Science Foundation of China [82060638]
- `Double 10-Thousand Plan' of Jiangxi Province (Innovation and Technology Professionals as the High-End Talent)
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Monoclonal antibody technology plays a vital role in biomedical and immunotherapy, and various techniques have been developed to generate different types of monoclonal antibodies, which have been widely used in disease research and treatment.
Monoclonal antibody technology plays a vital role in biomedical and immunotherapy, which greatly promotes the study of the structure and function of genes and proteins. To date, monoclonal antibodies have gone through four stages: murine monoclonal antibody, chimeric monoclonal antibody, humanised monoclonal antibody and fully human monoclonal antibody; thousands of monoclonal antibodies have been used in the fields of biology and medicine, playing a special role in the pathogenesis, diagnosis and treatment of disease. In this review, we compare the advantages and disadvantages of hybridoma technology, phage display technology, ribosome display technology, transgenic mouse technology, single B cell monoclonal antibody generation technologies, and forecast the promising applications of these technologies in clinical medicine, disease diagnosis and tumour treatment.
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