Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms23020905
Keywords
rheumatoid arthritis; epidemiology; diagnosis; pathogenesis; autoantibodies; precision medicine
Funding
- The Catholic University of Korea
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Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, and recent advancements have shed light on the underlying mechanisms, providing new therapeutic targets.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.
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