Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/ijms222413516
Keywords
cyclodextrin; hydrogel; preparation; release; degradation
Funding
- National Natural Science Foundation of China [31660490]
- Enterprise Cooperation Project [CP/003/2018]
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Cyclodextrin (CD) can be incorporated into hydrogels to form chemically or physically cross-linked networks, making it an ideal vehicle for delivering active ingredients to target tissues. This review discusses preparation methods, biomedical applications, release and degradation processes of CD-containing hydrogels under different conditions, as well as current challenges and future research directions.
Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.
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