Calcium in Neuronal and Glial Response to Axotomy

Neurotrauma assumes an instant or delayed disconnection of axons (axotomy), which affects not only neurons, but surrounding glia as well. Not only mechanically injured glia near the site of disconnection, especially transection, is subjected to the damage, but also glia that is remote from the lesion site. Glial cells, which surround the neuronal body, in turn, support neuron survival, so there is a mutual protection between neuron and glia. Calcium signaling is a central mediator of all post-axotomy events, both in neuron and glia, playing a critical role in their survival/regeneration or death/degeneration. The involvement of calcium in post-axotomy survival of the remote, mechanically intact glia is poorly studied. The purpose of this review is to sum up the calcium-involving mechanisms in responses of neurons and glial cells to axotomy to show their importance and to give some suggestions for future research of remote glia in this context.

Automated summary

Neurotrauma can lead to the disconnection of axons, impacting both neurons and surrounding glial cells. Calcium signaling plays a crucial role in post-axotomy events, affecting the survival or degeneration of neurons and glial cells. Future research should focus on understanding the survival mechanisms of remote glial cells from the lesion site after axotomy.