Influence of Incorporation of Different dn-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Properties

Three new compounds, namely [HL](2)(+)[CuCl4](2-), [HL](2)(+)[ZnCl4](2-), and [HL](2)(+)[CdCl4](2-) (where L: imipramine) were synthesized and their physicochemical and biological properties were thoroughly investigated. All three compounds form isostructural, crystalline systems, which have been studied using Single-Crystal X-ray diffraction analysis (SC-XRD) and Fourier-transform infrared spectroscopy (FTIR). The thermal stability was investigated using thermogravimetric analysis (TGA) and melting points for all compounds have been determined. Magnetic measurements were performed in order to study the magnetic properties of the compounds. The above mentioned techniques allowed us to comprehensively examine the physicochemical properties of the newly obtained compounds. The biological activity was investigated using the number of Zebrafish tests, as it is one of the most common models for studying the impact of newly synthesized compounds on the central nervous system (CNS), since this model is very similar to the human CNS.

Automated summary

Three new compounds with similar physicochemical properties were synthesized and studied, including their crystalline systems, thermal stability, and magnetic properties. The biological activity of these compounds on the central nervous system was investigated using Zebrafish tests, showing a certain level of impact.