4.7 Article

Atrial Fibrillation and Aortic Ectasia as Complications of Primary Aldosteronism: Focus on Pathophysiological Aspects

Journal

Publisher

MDPI
DOI: 10.3390/ijms23042111

Keywords

primary aldosteronism; aldosterone; atrial fibrillation; aortic ectasia; cardiovascular risk; hypokalemia; adrenal glands; secondary hypertension; endocrine hypertension

Funding

  1. [739543]

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Primary aldosteronism, the most common cause of secondary hypertension, not only affects blood pressure and electrolyte balance, but also has pro-inflammatory, pro-oxidant, and pro-fibrotic effects on the kidney, blood vessels, and heart, leading to potential harmful consequences. Clinical studies have shown that primary aldosteronism is associated with an increased risk of atrial fibrillation and aortic ectasia.
Primary aldosteronism (PA) is the most common cause of secondary hypertension. A growing body of evidence has suggested that, beyond its well-known effects on blood pressure and electrolyte balance, aldosterone excess can exert pro-inflammatory, pro-oxidant and pro-fibrotic effects on the kidney, blood vessels and heart, leading to potentially harmful pathophysiological consequences. In clinical studies, PA has been associated with an increased risk of cardiovascular, cerebrovascular, renal and metabolic complication compared to essential hypertension, including atrial fibrillation (AF) and aortic ectasia. An increased prevalence of AF in patients with PA has been demonstrated in several clinical studies. Aldosterone excess seems to be involved in the pathogenesis of AF by inducing cardiac structural and electrical remodeling that in turn predisposes to arrhythmogenicity. The association between PA and aortic ectasia is less established, but several studies have demonstrated an effect of aldosterone on aortic stiffness, vascular smooth muscle cells and media composition that, in turn, might lead to an increased risk of aortic dilation and dissection. In this review, we focus on the current evidence regarding the potential role of aldosterone excess in the pathogenesis of AF and aortic ectasia.

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