Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms23031088
Keywords
superparamagnetic iron oxide nanoparticles; human serum; single-particle inductively coupled plasma tandem mass spectrometry
Funding
- National Science Centre, Poland [2018/29/B/ST4/00178]
- Warsaw University of Technology
- Russian Science Foundation [21-13-00267]
- IDUB project (Scholarship Plus program)
- Russian Science Foundation [21-13-00267] Funding Source: Russian Science Foundation
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This study presents a versatile method for studying interactions between SPIONs and proteins. By monitoring changes in size distribution when exposed to human serum, the formation of stable protein corona and particle disaggregation were revealed.
Progress toward translating superparamagnetic iron oxide nanoparticles (SPIONs) with specific diagnostic and therapeutic properties for clinical applications depends on developing and implementing appropriate methodologies that would allow in-depth characterizations of their behavior in a real biological environment. Herein, we report a versatile approach for studying interactions between SPIONs and proteins using single-particle inductively coupled plasma tandem mass spectrometry. By monitoring the changes in the size distribution upon exposure to human serum, the formation of stable protein corona is revealed, accompanied by particle disaggregation.
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