Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms23020807
Keywords
diabetes mellitus; diabetic nephropathy; vitamin D
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Vitamin D may play a significant role in the development of diabetic nephropathy, but its influence on the reversal of existing renal damage remains uncertain. Several hypotheses suggest a link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation.
According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.
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