Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/ijms222111406
Keywords
acute kidney injury; mesenchymal stem cells; extracellular vesicles
Funding
- Yin Yen-Liang Foundation Development and Construction Plan of the School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan [107F-M01-0504, 107F-M01-0510]
- Ministry of Science and Technology, Taiwan [MOST 108-2923-B-010-002-MY3, MOST 109-2314-B-010-053-MY3, MOST 109-2811-B-010-532, MOST 109-2926-I-010-502, MOST 109-2823-8-010-003-CV, MOST 109-2622-B-010-006, MOST 109-2321-B-010-006, MOST 110-2923-B-A49A-501-MY3, MOST 110-2321-B-A49-003]
- Taipei Veterans General Hospital, Taiwan [V106D25-003-MY3, VGHUST107-G5-3-3, VGHUST109-V51-2, V110C-194]
- Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) from The Featured Areas Research Center Program within Ministry of Education (MOE) in Taiwan
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Mesenchymal stem cells (MSCs) and MSC-derived EVs are considered promising cellular therapies for treating AKI, as they benefit kidney regeneration by releasing paracrine factors and extracellular vesicles. Research aims to deepen the understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells, in order to develop more effective therapies for AKI.
Acute kidney injury (AKI) causes a lot of harm to human health but is treated by only supportive therapy in most cases. Recent evidence shows that mesenchymal stem cells (MSCs) benefit kidney regeneration through releasing paracrine factors and extracellular vesicles (EVs) to the recipient kidney cells and are considered to be promising cellular therapy for AKI. To develop more efficient, precise therapies for AKI, we review the therapeutic mechanism of MSCs and MSC-derived EVs in AKI and look for a better understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells. We also review recent clinical trials of MSC-EVs in AKI. This review summarizes the molecular mechanisms of MSCs' therapeutic effects on kidney regeneration, expecting to comprehensively facilitate future clinical application for treating AKI.
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