Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms222212152
Keywords
Pseudomonas aeruginosa; virulence; two-component system (tcs); biofilm; motility; pyocyanin; cytotoxins
Funding
- National Research Foundation (NRF) of Korea [2020R1I1A1A01070592, 2017M3A9E4078553]
- National Research Foundation of Korea [2020R1I1A1A01070592] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Pseudomonas aeruginosa is an opportunistic pathogen with potential threat to human health worldwide due to its high virulence and significant resistance to multiple antibiotics. Understanding the mechanism of two-component systems in controlling virulence factors during infection is crucial for developing new antibiotics to treat diseases caused by P. aeruginosa.
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a wide range of virulence factors. P. aeruginosa poses a potential threat to human health worldwide due to its omnipresent nature, robust host accumulation, high virulence, and significant resistance to multiple antibiotics. The pathogenicity of P. aeruginosa, which is associated with acute and chronic infections, is linked with multiple virulence factors and associated secretion systems, such as the ability to form and utilize a biofilm, pili, flagella, alginate, pyocyanin, proteases, and toxins. Two-component systems (TCSs) of P. aeruginosa perform an essential role in controlling virulence factors in response to internal and external stimuli. Therefore, understanding the mechanism of TCSs to perceive and respond to signals from the environment and control the production of virulence factors during infection is essential to understanding the diseases caused by P. aeruginosa infection and further develop new antibiotics to treat this pathogen. This review discusses the important virulence factors of P. aeruginosa and the understanding of their regulation through TCSs by focusing on biofilm, motility, pyocyanin, and cytotoxins.
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