Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/ijms222413454
Keywords
endogenous regenerative medicine; bone regeneration; dental regeneration; decellularized extracellular matrix; growth factors; extracellular vesicles; miRNAs
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Cell-free therapy has rapidly developed in regenerative medicine over the past decade, aiming to control and enhance tissue repair processes by understanding molecular mechanisms and signaling pathways. The concept of endogenous regenerative medicine, involving the recruitment/homing of endogenous stem cells, has advantages in overcoming limitations and risks associated with cell therapy. Cell-free products such as decellularized extracellular matrix, growth factors, extracellular vesicles, and miRNAs show potential in endogenous bone and dental regeneration.
An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.
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