Related references
Note: Only part of the references are listed.ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation
Marcus Borenas et al.
EMBO JOURNAL (2021)
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling
Farzaneh Aboualizadeh et al.
JOURNAL OF MOLECULAR BIOLOGY (2021)
Development of the sympathetic trunks in human embryos
Nutmethee Kruepunga et al.
JOURNAL OF ANATOMY (2021)
Targeting MYCN in Pediatric and Adult Cancers
Zhihui Liu et al.
FRONTIERS IN ONCOLOGY (2021)
Anaplastic lymphoma kinase (alk), a neuroblastoma associated gene, is expressed in neural crest domains during embryonic development of Xenopus
Marcela M. Moreno et al.
GENE EXPRESSION PATTERNS (2021)
Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements
Niloufar Javanmardi et al.
GENES CHROMOSOMES & CANCER (2020)
The prognostic roles of and correlation between ALK and MYCN protein expression in neuroblastoma
Hsiu-Hao Chang et al.
JOURNAL OF CLINICAL PATHOLOGY (2020)
The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness
Liselot M. Mus et al.
SCIENTIFIC REPORTS (2020)
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma
Joachim Tetteh Siaw et al.
CELL REPORTS (2020)
Targeting anaplastic lymphoma kinase in neuroblastoma
Ganesh Umapathy et al.
APMIS (2019)
The roles played by the MYCN, Trk, and ALK genes in neuroblastoma and neural development
Mayumi Higashi et al.
SURGERY TODAY (2019)
Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma
Shunsuke Kimura et al.
ONCOLOGY LETTERS (2019)
Neuroblastoma - A Neural Crest Derived Embryonal Malignancy
John Inge Johnsen et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia
Lucie Vivancos Stalin et al.
FRONTIERS IN ONCOLOGY (2019)
Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis
Sachie Ono et al.
GENESIS (2019)
The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis
Stephen P. Ducray et al.
CANCERS (2019)
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK)
Xiaotian Kong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Specification and formation of the neural crest: Perspectives on lineage segregation
Maneeshi S. Prasad et al.
GENESIS (2019)
A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans
Glenn S. Wolfe et al.
ENEURO (2019)
Anaplastic Lymphoma Kinase Mutation (ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib
Benedito A. Carneiro et al.
CLINICAL CANCER RESEARCH (2018)
Schwann cell precursor: a neural crest cell in disguise?
Alessandro Furlan et al.
DEVELOPMENTAL BIOLOGY (2018)
MAPK and PI3K signaling: At the crossroads of neural crest development
Colin J. Dinsmore et al.
DEVELOPMENTAL BIOLOGY (2018)
Next generation sequencing reveals a novel ALK G1128A mutation resistant to crizotinib in an ALK-Rearranged NSCLC patient
Xinghao Ai et al.
LUNG CANCER (2018)
Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis
Lucille Lopez-Delisle et al.
ONCOGENE (2018)
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells
Andrey Fadeev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma
Laura Kerosuo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
Sandra G. Gonzalez Malagon et al.
NATURE COMMUNICATIONS (2018)
ALK in Neuroblastoma: Biological and Therapeutic Implications
Ricky M. Trigg et al.
CANCERS (2018)
Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells
Felipe Monteleone Vieceli et al.
DEVELOPMENT (2018)
Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces
Hao Huang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma
Kristina B. Emdal et al.
SCIENCE SIGNALING (2018)
Neuroblastoma pathogenesis: deregulation of embryonic neural crest development
Julie A. Tomolonis et al.
CELL AND TISSUE RESEARCH (2018)
Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators
Minchul Seo et al.
CELL ADHESION & MIGRATION (2017)
Overview and recent advances in the treatment of neuroblastoma
Sarah B. Whittle et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2017)
Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans
Tomohiro Kitazono et al.
JOURNAL OF NEUROSCIENCE (2017)
Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk
Elizabeth S. Mo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Alessandro Furlan et al.
SCIENCE (2017)
Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation
Jikui Guan et al.
CANCERS (2017)
The role of anaplastic lymphoma kinase in pediatric cancers
Junko Takita
CANCER SCIENCE (2017)
Microenvironment-Driven Shift of Cohesion/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma
Celine Delloye-Bourgeois et al.
CANCER CELL (2017)
The role of the ALK receptor in cancer biology
B. Hallberg et al.
ANNALS OF ONCOLOGY (2016)
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling
Marco Kramer et al.
JOURNAL OF NEUROSCIENCE (2016)
Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival
Andrey Fadeev et al.
PIGMENT CELL & MELANOMA RESEARCH (2016)
Neuroblastoma
Katherine K. Matthay et al.
NATURE REVIEWS DISEASE PRIMERS (2016)
Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment
Irina Lambertz et al.
CLINICAL CANCER RESEARCH (2015)
Establishing neural crest identity: a gene regulatory recipe
Marcos Simoes-Costa et al.
DEVELOPMENT (2015)
Sympathoadrenal neural crest cells: The known, unknown and forgotten?
Rachael Lumb et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2015)
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Thomas F. Eleveld et al.
NATURE GENETICS (2015)
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions
Andrey V. Reshetnyak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Intragenic Anaplastic Lymphoma Kinase (ALK) Rearrangements: Translocations as a Novel Mechanism of ALK Activation in Neuroblastoma Tumors
Susanne Fransson et al.
GENES CHROMOSOMES & CANCER (2015)
ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma
Scott C. Bresler et al.
CANCER CELL (2014)
Emergence of New ALK Mutations at Relapse of Neuroblastoma
Gudrun Schleiermacher et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
The Drosophila Midkine/Pleiotrophin Homologues Miple1 and Miple2 Affect Adult Lifespan but Are Dispensable for Alk Signaling during Embryonic Gut Formation
Fredrik Hugosson et al.
PLOS ONE (2014)
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
Hongbing Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma
Ganesh Umapathy et al.
SCIENCE SIGNALING (2014)
Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells
Gisele Montavon et al.
ONCOTARGET (2014)
Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma
Alex Cazes et al.
ONCOTARGET (2014)
Neuroblastoma of Undifferentiated Subtype, Prognostic Significance of Prominent Nucleolar Formation, and MYC/MYCN Protein Expression
Larry L. Wang et al.
CANCER (2013)
Characterization of Rearrangements Involving the ALK Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma
Alex Cazes et al.
CANCER RESEARCH (2013)
FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Evan E. Santo et al.
CANCER RESEARCH (2013)
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
Damini Chand et al.
DISEASE MODELS & MECHANISMS (2013)
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
Kamaraj Sattu et al.
FEBS JOURNAL (2013)
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh et al.
NATURE GENETICS (2013)
Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo
Stella Shtukmaster et al.
NEURAL DEVELOPMENT (2013)
Retinoic Acid Upregulates Ret and Induces Chain Migration and Population Expansion in Vagal Neural Crest Cells to Colonise the Embryonic Gut
Johanna E. Simkin et al.
PLOS ONE (2013)
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2013)
ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma
Md. Kamrul Hasan et al.
SCIENTIFIC REPORTS (2013)
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
Bengt Hallberg et al.
NATURE REVIEWS CANCER (2013)
The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma
Teeara Berry et al.
CANCER CELL (2012)
Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis
Shizhen Zhu et al.
CANCER CELL (2012)
Copy number status and mutation analyses of anaplastic lymphoma kinase (ALK) gene in 90 sporadic neuroblastoma tumors
Ozkan Bagci et al.
CANCER LETTERS (2012)
NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis
S. R. P. McDonnell et al.
ONCOGENE (2012)
Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
J. Okubo et al.
ONCOGENE (2012)
Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice
Lukas C. Heukamp et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Appearance of the Novel Activating F1174S ALK Mutation in Neuroblastoma Correlates with Aggressive Tumor Progression and Unresponsiveness to Therapy
Tommy Martinsson et al.
CANCER RESEARCH (2011)
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition
Tobias Reiff et al.
DEVELOPMENT (2011)
The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking
P. Mazot et al.
ONCOGENE (2011)
The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo
Christina Schonherr et al.
TRANSLATIONAL ONCOLOGY (2011)
GSK-3 inhibitors: preclinical and clinical focus on CNS
Hagit Eldar-Finkelman et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain
Christian C. Lee et al.
BIOCHEMICAL JOURNAL (2010)
Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors
Roberto T. Bossi et al.
BIOCHEMISTRY (2010)
Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Sara De Brouwer et al.
CLINICAL CANCER RESEARCH (2010)
Neuroblastoma: Biology, Prognosis, and Treatment
Julie R. Park et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2010)
Involvement of Grb2 Adaptor Protein in Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK)-mediated Signaling and Anaplastic Large Cell Lymphoma Growth
Ludovica Riera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Dependence receptors: a new paradigm in cell signaling and cancer therapy
D. Goldschneider et al.
ONCOGENE (2010)
Anaplastic lymphoma kinase: signalling in development and disease
Ruth H. Palmer et al.
BIOCHEMICAL JOURNAL (2009)
Comprehensive Spatiotemporal Analysis of Early Chick Neural Crest Network Genes
Jane Khudyakov et al.
DEVELOPMENTAL DYNAMICS (2009)
Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma
Isabelle Janoueix-Lerosey et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Long-Term Results for Children With High-Risk Neuroblastoma Treated on a Randomized Trial of Myeloablative Therapy Followed by 13-cis-Retinoic Acid: A Children's Oncology Group Study
Katherine K. Matthay et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
The epidemiology of neuroblastoma: a review
Julia E. Heck et al.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2009)
High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours
Helena Caren et al.
BIOCHEMICAL JOURNAL (2008)
C-elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-β signaling
David J. Reiner et al.
CURRENT BIOLOGY (2008)
Identification of ALK as a major familial neuroblastoma predisposition gene
Yael P. Mosse et al.
NATURE (2008)
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
NATURE (2008)
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
NATURE (2008)
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
NATURE (2008)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
Klarisa Rikova et al.
CELL (2007)
In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?
Thomas Mathivet et al.
CELLULAR SIGNALLING (2007)
Anaplastic lymphoma kinase is activated through the Pleiotrophin/Receptor protein-tyrosine phosphatase β/ζ signaling pathway -: An alternative mechanism of receptor tyrosine kinase activation
Pablo Perez-Pinera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
Manabu Soda et al.
NATURE (2007)
ALK is a novel dependence receptor - Potential implications in development and cancer
Michele Allouche
CELL CYCLE (2007)
The ligand jelly belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK
Hai-Ling Yang et al.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION (2007)
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
Joffrey Degoutin et al.
FEBS LETTERS (2007)
Recruitment of insulin receptor substrate-1 and activation of NF-κB essential for midkine growth signaling through anaplastic lymphoma kinase
A. H. Kuo et al.
ONCOGENE (2007)
The sympathoadrenal cell lineage: Specification, diversification, and new perspectives
Katrin Huber
DEVELOPMENTAL BIOLOGY (2006)
Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage
Jaouhar Mourali et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Characterization of the expression of the ALK receptor tyrosine kinase in mice
E Vernersson et al.
GENE EXPRESSION PATTERNS (2006)
Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system
SP Hurley et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2006)
Neural precursor cycling at sonic speed - N-Myc pedals, GSK-3 brakes
PS Knoepfler et al.
CELL CYCLE (2006)
Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
C Moog-Lutz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Unique substrate specificity of anaplastic lymphoma kinase (ALK): Development of phosphoacceptor peptides for the assay of ALK activity
A Donella-Deana et al.
BIOCHEMISTRY (2005)
Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma
D Trochet et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells
F Armstrong et al.
ONCOGENE (2004)
NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a
TL Gu et al.
BLOOD (2004)
Anaplastic lymphoma kinase proteins in growth control and cancer
K Pulford et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
C Englund et al.
NATURE (2003)
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers
HH Lee et al.
NATURE (2003)
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
CE Lorén et al.
EMBO REPORTS (2003)
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
PS Knoepfler et al.
GENES & DEVELOPMENT (2002)
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
GE Stoica et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines
I Miyake et al.
ONCOGENE (2002)
HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans
T Ishihara et al.
CELL (2002)
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
C Powers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
A Zamo et al.
ONCOGENE (2002)
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
Q Zhang et al.
JOURNAL OF IMMUNOLOGY (2002)
Identification and characterization of DAlk:: a novel Drosophila melanogaster RTK which drives ERK activation in vivo
CE Lorén et al.
GENES TO CELLS (2001)
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
GE Stoica et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
RY Bai et al.
BLOOD (2000)