Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms222212489
Keywords
skin aging; intrinsic aging; photoaging; molecular mechanisms
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science [2019R1F1A1059460]
- National Research Foundation of Korea [2019R1F1A1059460] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Skin aging is a complex process influenced by intrinsic and extrinsic factors, which affect the structure and function of the skin. Aging skin typically shows epidermal atrophy and decreased cell numbers in the dermis, affecting fibroblast function.
Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell numbers. The dermis of aged skin shows decreased numbers of mast cells and fibroblasts. Fibroblast senescence contributes to skin aging by secreting a senescence-associated secretory phenotype, which decreases proliferation by impairing the release of essential growth factors and enhancing degradation of the extracellular matrix through activation of matrix metalloproteinases (MMPs). Several molecular mechanisms affect skin aging including telomere shortening, oxidative stress and MMP, cytokines, autophagic control, microRNAs, and the microbiome. Accumulating evidence on the molecular mechanisms of skin aging has provided clinicians with a wide range of therapeutic targets for treating aging skin.
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