4.7 Article

The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus

Related references

Note: Only part of the references are listed.
Article Cell Biology

The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites

Sarah D. Neuman et al.

Summary: Membrane contact sites play crucial roles in organelle signaling and communication. This study reveals a novel role for the Hobbit proteins at endoplasmic reticulum-plasma membrane (ER-PM) contact sites, demonstrating their localization and interaction with plasma membrane phosphatidylinositols. Furthermore, the essentiality of Hobbit protein in Drosophila development makes it one of the first examples of a membrane contact site-localized lipid binding protein required for viability.

JOURNAL OF CELL SCIENCE (2022)

Review Biochemistry & Molecular Biology

Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport

Marianna Leonzino et al.

Summary: Recent studies have discovered a novel protein-mediated mechanism of lipid transport, where a rod-like protein bridge with a hydrophobic groove facilitates the transfer of lipids between organelles in eukaryotic cells. This mechanism is well-suited for bulk transport of bilayer lipids to promote membrane growth.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

Review Cell Biology

The Complex Dance of Organelles during Mitochondrial Division

Luis-Carlos Tabara et al.

Summary: Mitochondria are dynamic organelles that can adapt to cellular needs through cycles of division and fusion events. Recent research has highlighted the important role of Golgi-derived PI4P-containing vesicles in the final steps of mitochondrial division, proposing a mechanism involving the recruitment of PI4P effectors and/or the actin nucleation machinery. Speculation on the necessity of a complex coordination of different organelles to facilitate mitochondrial membrane remodeling is also discussed.

TRENDS IN CELL BIOLOGY (2021)

Review Medicine, Research & Experimental

The role of the Golgi apparatus in disease (Review)

Jianyang Liu et al.

Summary: The Golgi apparatus plays a crucial role in cellular homeostasis and is linked to various diseases. Mutations in genes encoding Golgi resident proteins can lead to diseases, typically involving defects in membrane trafficking, protein mislocalization, and impaired glycosylation. Detection of Golgi resident proteins in human serum samples may serve as a diagnostic tool, while the central role of Golgi apparatus in membrane trafficking pathways presents potential targets for disease therapy.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Targeting Copper Homeostasis Improves Functioning of vps13Δ Yeast Mutant Cells, a Model of VPS13-Related Diseases

Piotr Soczewka et al.

Summary: Ion homeostasis is crucial for organism functioning, with copper and iron imbalances associated with various neurological diseases. The study using yeast as a model organism identified potential therapeutic targets related to copper and iron homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites

Samantha Katarzyna Dziurdzik et al.

Summary: The conserved VPS13 proteins are a new family of lipid transporters at membrane contact sites, with mutations in human homologs linked to neurological disorders. Yeast serves as a useful model system to study Vps13 function at different organelles and determine the factors responsible for its membrane targeting. Recent advances in understanding VPS13 proteins, focusing on yeast research, are described in this review.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D-TSG101 interactions

Jingru Wang et al.

Summary: Upon starvation, cells switch to mitochondrial oxidation of fatty acids from glucose-based metabolism. VPS13D and ESCRT complex remodel lipid droplet (LD) membranes to promote fatty acid trafficking to mitochondria.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

VPS13D promotes peroxisome biogenesis

Heather A. Baldwin et al.

Summary: The VPS13 gene family in mammals consists of VPS13A-D, with VPS13D playing a crucial role in regulating peroxisome biogenesis.

JOURNAL OF CELL BIOLOGY (2021)

Article Cell Biology

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

Andres Guillen-Samander et al.

Summary: The research reveals that Miro, a protein related to the function of Gem1 in yeast and higher eukaryotes, can recruit the lipid transport protein VPS13D, providing a lipid conduit between the endoplasmic reticulum and mitochondria. This discovery highlights a missing link between the functions of Gem1/Miro in yeast and higher eukaryotes, with potential implications for Parkinson's disease pathogenesis.

JOURNAL OF CELL BIOLOGY (2021)

Article Cell Biology

Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation

Carolyn M. Highland et al.

Summary: Proper function of the Golgi complex depends on the activity of Arf1, which controls PI4P production to initiate the final stages of Golgi maturation, facilitating AP-1 and secretory vesicle formation. This study reveals the crucial roles of Arf1 and PI4P in Golgi organelle function and maturation process.

MOLECULAR BIOLOGY OF THE CELL (2021)

Review Cell Biology

ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi

Petia Adarska et al.

Summary: Molecular switches of the ADP-ribosylation factor (ARF) GTPase family play crucial roles in coordinating intracellular trafficking, including membrane deformation, cargo sorting, and recruitment of downstream coat proteins and effectors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro

Damian Kolakowski et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Review Cell Biology

Clathrin's life beyond 40: Connecting biochemistry with physiology and disease

Kit Briant et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Phosphatidylinositol 4,5-bisphosphate in the Control of Membrane Trafficking

Suhua Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Cell Biology

Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

Jose Angel Martinez-Menarguez et al.

CELLS (2019)

Review Biochemistry & Molecular Biology

Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling

Prajakta Kulkarni-Gosavi et al.

FEBS LETTERS (2019)

Review Genetics & Heredity

Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome

Kevin Peikert et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2018)

Article Clinical Neurology

Recessive mutations in >VPS13D cause childhood onset movement disorders

Julie Gauthier et al.

ANNALS OF NEUROLOGY (2018)

Article Clinical Neurology

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

Eunju Seong et al.

ANNALS OF NEUROLOGY (2018)

Article Cell Biology

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites

Bjorn D. M. Bean et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

Johan-Owen De Craene et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Cell Biology

Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites

Arun T. John Peter et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Phosphatidylinositol-3-phosphate regulates response of cells to proteotoxic stress

Joanna Kaminska et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Cell Biology

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

Jae-Sook Park et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Article Cell Biology

Chorein Sensitive Arrangement of Cytoskeletal Architecture

Sabina Honisch et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Article Cell Biology

ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

Alexander B. Lang et al.

JOURNAL OF CELL BIOLOGY (2015)

Editorial Material Cell Biology

StARTing to understand membrane contact sites

Ayelen Gonzalez Montoro et al.

TRENDS IN CELL BIOLOGY (2015)

Review Neurosciences

Golgi fragmentation in Alzheimer's disease

Gunjan Joshi et al.

FRONTIERS IN NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

The small GTPase Arf1 modulates mitochondrial morphology and function

Karin B. Ackema et al.

EMBO JOURNAL (2014)

Article Biochemistry & Molecular Biology

Cohen syndrome is associated with major glycosylation defects

Laurence Duplomb et al.

HUMAN MOLECULAR GENETICS (2014)

Review Cell Biology

Adaptor proteins involved in polarized sorting

Juan S. Bonifacino

JOURNAL OF CELL BIOLOGY (2014)

Article Cell Biology

Arfs at a Glance

Catherine L. Jackson et al.

JOURNAL OF CELL SCIENCE (2014)

Article Cell Biology

Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

Tom Kirchhausen et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Cell Biology

Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

Ioana Alesutan et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Clathrin, adaptors and disease: Insights from the yeast Saccharomyces cerevisiae

Margaret D. Myers et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2013)

Article Cell Biology

Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis

Tao Tan et al.

JOURNAL OF CELL SCIENCE (2013)

Article Cell Biology

The Sec7 Arf-GEF Is Recruited to the trans-Golgi Network by Positive Feedback

Brian C. Richardson et al.

DEVELOPMENTAL CELL (2012)

Article Cell Biology

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

Jae-Sook Park et al.

JOURNAL OF CELL SCIENCE (2012)

Article Biochemistry & Molecular Biology

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

Wenke Seifert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Cell Biology

ARF family G proteins and their regulators: roles in membrane transport, development and disease

Julie G. Donaldson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Review Genetics & Heredity

Neuroacanthocytosis Syndromes

Hans H. Jung et al.

ORPHANET JOURNAL OF RARE DISEASES (2011)

Article Biochemistry & Molecular Biology

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

Brett A. McCray et al.

HUMAN MOLECULAR GENETICS (2010)

Article Genetics & Heredity

Movement disorder and neuronal migration disorder due to ARFGEF2 mutation

M. C. Y. de Wit et al.

NEUROGENETICS (2009)

Article Cell Biology

Yeast Arf3p modulates plasma membrane Ptdlns(4,5)P2 levels to facilitate endocytosis

Iwona I. Smaczynska-de Rooij et al.

TRAFFIC (2008)

Review Genetics & Heredity

Exploring genetic interactions and networks with yeast

Charles Boone et al.

NATURE REVIEWS GENETICS (2007)

Article Multidisciplinary Sciences

Live imaging of yeast Golgi cisternal maturation

Kumi Matsuura-Tokita et al.

NATURE (2006)

Review Cell Biology

ARF proteins: roles in membrane traffic and beyond

C D'Souza-Schorey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Genome-wide analysis of membrane targeting by S-cerevisiae pleckstrin homology domains

JW Yu et al.

MOLECULAR CELL (2004)

Article Biotechnology & Applied Microbiology

Analysis of the human VPS13 gene family

A Velayos-Baeza et al.

GENOMICS (2004)

Review Cell Biology

Opinion - Coat proteins: shaping membrane transport

JS Bonifacino et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)