4.7 Review

Phytoestrogens (Resveratrol and Equol) for Estrogen-Deficient Skin-Controversies/Misinformation versus Anti-Aging In Vitro and Clinical Evidence via Nutraceutical-Cosmetics

Related references

Note: Only part of the references are listed.
Review Food Science & Technology

Food-derived bioactive compounds with anti-aging potential for nutricosmetic and cosmeceutical products

David Fonseca Hernandez et al.

Summary: Food contains bioactive compounds with diverse biological activities, used in the cosmetic industry for nutricosmetic and cosmeceutical products aimed at reducing skin aging and inflammation. Phytochemicals from fruits, vegetables, herbs, and plants are being utilized for their anti-aging potential. These compounds have antioxidant and biological properties that modulate molecular markers involved in the aging process.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

Review Chemistry, Applied

Polyphenols and their applications: An approach in food chemistry and innovation potential

Fabio Fernandes de Araujo et al.

Summary: Polyphenols are naturally occurring compounds present in fruits and vegetables, with various biological effects and industrial applications. Adequate intake of polyphenols can help prevent diseases and improve the properties of starch, as well as contribute to innovation in different technological fields.

FOOD CHEMISTRY (2021)

Article Chemistry, Applied

Physical and phytochemical composition of 23 Portuguese sweet cherries as conditioned by variety (or genotype)

Ana C. Goncalves et al.

Summary: This study analyzed the physicochemical characteristics and phenolic profile of twenty-three sweet cherry cultivars from Fundao region, Portugal. Different cultivars showed variations in physical properties and phenolic compounds, with Sunburst and Sweetheart having high color values, while Sunburst and Brook's were richest in non-colored phenolics, and Garnet and Tavora were richest in anthocyanins.

FOOD CHEMISTRY (2021)

Review Dermatology

Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin

Edwin D. Lephart et al.

Summary: After menopause, estradiol levels decrease significantly, leading to adverse skin changes such as atrophy and wrinkles. While traditional local hormone treatments are effective in reversing aging skin deterioration, the long-term effects of systemic menopausal treatment remain uncertain, prompting the development of newer therapeutic agents like selective estrogen receptor modulators (SERMs), including phytoestrogens, for the treatment of estrogen-deficient skin.

DERMATOLOGY AND THERAPY (2021)

Article Reproductive Biology

Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies

Katharine E. Reed et al.

Summary: Studies have shown that regardless of the dose and duration of soy protein or isoflavone intake, there is no significant effect on testosterone or estrogen levels in men.

REPRODUCTIVE TOXICOLOGY (2021)

Review Biochemistry & Molecular Biology

The Potential Effects of Phytoestrogens: The Role in Neuroprotection

Justyna Gorzkiewicz et al.

Summary: Phytoestrogens have potential health benefits in reducing menopausal symptoms, osteoporosis, cardiovascular disease, and brain disease risk, while also exhibiting inhibitory effects on cancer.

MOLECULES (2021)

Article Biotechnology & Applied Microbiology

Trends in the use of marine ingredients in anti-aging cosmetics

Diana I. S. P. Resende et al.

Summary: The growing interest among consumers in natural bioactive compounds has driven the evolution of the skin care industry, leading to an increase in the use of marine ingredients in anti-aging products. Algae, particularly red algae, are the most commonly used marine ingredient in these formulations, while the use of marine bacteria has decreased over time.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2021)

Review Biochemistry & Molecular Biology

Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective

Cristina Hernando et al.

Summary: ER+ breast cancer is the most common subtype, with endocrine therapy being the fundamental treatment. However, some patients develop endocrine resistance, with ESR1 gene mutations being a studied mechanism. SERDs have become a weapon against endocrine resistance in research and development, showing promise for improving patient outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

A role for estrogen in skin ageing and dermal biomechanics

Holly N. Wilkinson et al.

Summary: The skin serves as the body's primary defence against external factors, and alterations due to ageing can increase the risk of skin disease and injury. Skin ageing is influenced by a combination of intrinsic and extrinsic factors, with estrogen playing a crucial role in maintaining skin structure and function. Therapies targeting estrogen receptors may help prevent and restore the mechanical defects associated with skin ageing.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Food Science & Technology

Determination of S- and/or R-equol in plant-based food products and efficacy of topical or oral 4′,7-isoflavandiol (R/S equol) to improve skin health in adult men, a Placebo-controlled pilot study

Edwin D. Lephart

Summary: The investigation aimed to determine the presence of S- and/or R-equol in plant-based food products and evaluate the effects of R/S equol on skin health in adult men. Results showed the presence of S- and/or R-equol in food products and demonstrated that topical or oral R/S equol had positive effects on improving skin health in men.

JOURNAL OF FUNCTIONAL FOODS (2021)

Review Biochemistry & Molecular Biology

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Il-Sup Kim

Summary: Soybeans are rich in proteins and lipids, as well as functional components such as isoflavones, which are structurally similar to estrogen and play a role in regulating estrogen in the human body. Isoflavones have diverse physiological functions, including anticancer, antioxidant, and anti-allergic effects.

ANTIOXIDANTS (2021)

Article Food Science & Technology

Antioxidant and reduced skin-ageing effects of a polyphenol-enriched dietary supplement in response to air pollution: a randomized, double-blind, placebo-controlled study

Vincenzo Nobile et al.

Summary: The study investigated the efficacy of a polyphenol-enriched dietary supplement in reducing pollution-induced oxidative stress and improving skin ageing parameters in Caucasian and Asian subjects. The results showed significant improvements in skin moisture, elasticity, pigmentation, and other skin parameters after only two weeks of product consumption, indicating that this supplement could be an effective complementary nutrition strategy to protect against the negative effects of environmental pollution exposure.

FOOD & NUTRITION RESEARCH (2021)

Article Biochemistry & Molecular Biology

4′,7-Isoflavandiol (Equol) Enhances Human Dermal Fibroblast Renewal and Has Effects Similar to 17β-Estradiol in Stimulating Collagen and Elastin Expression. Cell Cycle and RT-PCR Analysis without Phenol Red

Edwin D. Lephart

Summary: Polyphenols like Equol can provide protection against photoaging by stimulating collagen and elastin synthesis and enhancing fibroblast renewal. Results show that Equol significantly increased fibroblast rejuvenation and collagen levels, as well as significantly elevated elastin gene expression levels in short-term cultures.

COSMETICS (2021)

Review Food Science & Technology

The bioactivities of resveratrol and its naturally occurring derivatives on skin

Ming-Hsien Lin et al.

Summary: Resveratrol and its derivatives have antioxidative activity that benefits in attenuating cutaneous neoplasia, photoaging, and inflammation, making them potential treatments for various skin disorders. This review highlights the chemical classification, treatment cases, and nanocarrier applications to enhance the efficacy of resveratrol in skin therapy.

JOURNAL OF FOOD AND DRUG ANALYSIS (2021)

Review Food Science & Technology

Feeding the skin: A new trend in food and cosmetics convergence

Catarina Faria-Silva et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

Review Food Science & Technology

Skin Health from the Inside Out

Brittany Woodby et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11 (2020)

Article Pharmacology & Pharmacy

Lignans: Quantitative Analysis of the Research Literature

Andy Wai Kan Yeung et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Health Care Sciences & Services

Menstrual Cycle Length and Patterns in a Global Cohort of Women Using a Mobile Phone App: Retrospective Cohort Study

Jessica A. Grieger et al.

JOURNAL OF MEDICAL INTERNET RESEARCH (2020)

Review Food Science & Technology

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Xiao Meng et al.

FOODS (2020)

Review Multidisciplinary Sciences

Plant Complexity and Cosmetic Innovation

Greta Faccio

ISCIENCE (2020)

Review Chemistry, Multidisciplinary

Potential of microalgal compounds in trending natural cosmetics: A review

Cagla Yarkent et al.

SUSTAINABLE CHEMISTRY AND PHARMACY (2020)

Review Pharmacology & Pharmacy

Therapeutic Potential of Equol: A Comprehensive Review

Atiya Fatima et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Article Obstetrics & Gynecology

Changes of androgens levels in menopausal women

Maria Brzozowska et al.

MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY (2020)

Review Food Science & Technology

New Insights on the Use of Polyphenols as Natural Preservatives and Their Emerging Safety Concerns

Fred Kwame Ofosu et al.

FRONTIERS IN SUSTAINABLE FOOD SYSTEMS (2020)

Review Pharmacology & Pharmacy

Topical use of resveratrol: technological aspects

Viliana Gugleva et al.

PHARMACIA (2020)

Review Biochemistry & Molecular Biology

Marine natural products

Anthony R. Carroll et al.

NATURAL PRODUCT REPORTS (2020)

Review Dermatology

Resveratrol as an active ingredient for cosmetic and dermatological applications: a review

Anna Ratz-Lyko et al.

JOURNAL OF COSMETIC AND LASER THERAPY (2019)

Article Nutrition & Dietetics

Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases

Marzena Pabich et al.

NUTRIENTS (2019)

Review Biochemistry & Molecular Biology

Resveratrol: Twenty Years of Growth, Development and Controversy

John M. Pezzuto

BIOMOLECULES & THERAPEUTICS (2019)

Review Biochemistry & Molecular Biology

Can Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?

Yong Chool Boo

ANTIOXIDANTS (2019)

Article Multidisciplinary Sciences

Systematic Review and Meta-analysis on the Effect of Soy on Thyroid Function

Jemiliat Otun et al.

SCIENTIFIC REPORTS (2019)

Article Dermatology

Skin care and cosmeceuticals: Attitudes and trends among trainees and educators

H. Jill Feetham et al.

JOURNAL OF COSMETIC DERMATOLOGY (2018)

Review Pharmacology & Pharmacy

Polyphenols and Microvascular Function in Humans: A Systematic Review

Kirsty A. Woodward et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Review Biochemistry & Molecular Biology

Effects of superfoods on risk factors of metabolic syndrome: a systematic review of human intervention trials

Jose J. van den Driessche et al.

FOOD & FUNCTION (2018)

Review Dermatology

A review of the role of estrogen in dermal aging and facial attractiveness in women

Edwin D. Lephart

JOURNAL OF COSMETIC DERMATOLOGY (2018)

Review Nutrition & Dietetics

Soy, Soy Foods and Their Role in Vegetarian Diets

Gianluca Rizzo et al.

NUTRIENTS (2018)

Review Biochemistry & Molecular Biology

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

David L. Vollmer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Obstetrics & Gynecology

Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms

Amanda Allshouse et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2018)

Article Endocrinology & Metabolism

The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study

Thozhukat Sathyapalan et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Effect of Soy in Men With Type 2 Diabetes Mellitus and Subclinical Hypogonadism: A Randomized Controlled Study

Thozhukat Sathyapalan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Medicine, Research & Experimental

Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

Edwin D. Lephart et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Resveratrol, 4′ Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health

Edwin D. Lephart

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology

Fernand Labrie et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Review Nutrition & Dietetics

Health impact of childhood and adolescent soy consumption

Mark Messina et al.

NUTRITION REVIEWS (2017)

Review Biochemistry & Molecular Biology

Resveratrol: from diet to topical usage

Veronica Sanda Chedea et al.

FOOD & FUNCTION (2017)

Article Chemistry, Applied

Topical equol preparation improves structural and molecular skin parameters nonxml

U. Magnet et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2017)

Article Chemistry, Medicinal

Synthesis and skin gene analysis of 4′-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications

Edwin D. Lephart et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Review Nutrition & Dietetics

Natural Polyphenols for Prevention and Treatment of Cancer

Yue Zhou et al.

NUTRIENTS (2016)

Review Pharmacology & Pharmacy

Estrogen Receptor Ligands: A Review (2013-2015)

Shabnam Farzaneh et al.

SCIENTIA PHARMACEUTICA (2016)

Article Biochemistry & Molecular Biology

Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts

Elena Pomari et al.

FASEB JOURNAL (2015)

Article Nutrition & Dietetics

Soy foods, isoflavones, and the health of postmenopausal women

Mark Messina

AMERICAN JOURNAL OF CLINICAL NUTRITION (2014)

Article Food Science & Technology

Resveratrol: influences on gene expression in human skin

Edwin D. Lephart et al.

JOURNAL OF FUNCTIONAL FOODS (2014)

Article Medicine, Research & Experimental

Nano- and micro-encapsulated systems for enhancing the delivery of resveratrol

Mary Ann Augustin et al.

RESVERATROL AND HEALTH (2013)

Article Oncology

Soy and Its Isoflavones: The Truth Behind the Science in Breast Cancer

Crystal C. Douglas et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2013)

Review Oncology

Equol, Adiponectin, Insulin Levels and Risk of Breast Cancer

Machiko Minatoya et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

Article Biochemistry & Molecular Biology

Phytoestrogens in Postmenopause: The State of the Art from a Chemical, Pharmacological and Regulatory Perspective

Elisabetta Poluzzi et al.

CURRENT MEDICINAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Steroidogenesis in the skin: Implications for local immune functions

Andrzej Slominski et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

Review Cell Biology

A Review of Pterostilbene Antioxidant Activity and Disease Modification

Denise McCormack et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Nutrition & Dietetics

Health-Promoting Components of Fruits and Vegetables in the Diet

Rui Hai Liu

ADVANCES IN NUTRITION (2013)

Review Biotechnology & Applied Microbiology

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

K. N. Venugopala et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Endocrinology & Metabolism

An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression

Dario Antonini et al.

Frontiers in Endocrinology (2013)

Article Dermatology

Estrogens and aging skin

M. Julie Thornton

DERMATO-ENDOCRINOLOGY (2013)

Article Environmental Sciences

Estrogenic activity in extracts and exudates of cyanobacteria and green algae

E. Sychrova et al.

ENVIRONMENT INTERNATIONAL (2012)

Review Endocrinology & Metabolism

Postmenopausal skin and estrogen

David F. Archer

GYNECOLOGICAL ENDOCRINOLOGY (2012)

Review Plant Sciences

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2012)

Article Obstetrics & Gynecology

The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial

Ayuko Oyama et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2012)

Article Biochemistry & Molecular Biology

Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities

Sitarina Widyarini et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2012)

Article Endocrinology & Metabolism

Update on genistein and thyroid: an overall message of safety

Herbert Marini et al.

FRONTIERS IN ENDOCRINOLOGY (2012)

Review Endocrinology & Metabolism

Postmenopausal skin and estrogen

David F. F. Archer

GYNECOLOGICAL ENDOCRINOLOGY (2012)

Article Biochemistry & Molecular Biology

Transcriptional activity of estrogen-related receptor gamma (ERR gamma) is stimulated by the phytoestrogen equol

Johanna Hirvonen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2011)

Article Cell Biology

The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis

Takayoshi Inoue et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Article Food Science & Technology

Urinary isoflavone phytoestrogens in German children and adolescents - A longitudinal examination in the DONALD cohort

Gisela H. Degen et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

Review Dermatology

Thyroid hormone action on skin

Joshua D. Safer

DERMATO-ENDOCRINOLOGY (2011)

Article Obstetrics & Gynecology

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

Jill M. Hamilton-Reeves et al.

FERTILITY AND STERILITY (2010)

Article Nutrition & Dietetics

Equol: Pharmacokinetics and Biological Actions

Kenneth D. R. Setchell et al.

JOURNAL OF NUTRITION (2010)

Article Nutrition & Dietetics

Equol: History, Chemistry, and Formation

Kenneth D. R. Setchell et al.

JOURNAL OF NUTRITION (2010)

Review Food Science & Technology

Resveratrol bioavailability and toxicity in humans

Charles-Henry Cottart et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2010)

Article Plant Sciences

Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies

Zhaohui Zhao et al.

PHYTOCHEMISTRY REVIEWS (2010)

Review Nutrition & Dietetics

Chemistry and Biochemistry of Dietary Polyphenols

Rong Tsao

NUTRIENTS (2010)

Review Food Science & Technology

Naturally Occurring Food Toxins

Laurie C. Dolan et al.

TOXINS (2010)

Article Nutrition & Dietetics

Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women

Jane Teas et al.

JOURNAL OF NUTRITION (2009)

Article Food Science & Technology

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

Luis Almeida et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2009)

Review Pharmacology & Pharmacy

History of cosmetics

S. K. Chaudhri et al.

ASIAN JOURNAL OF PHARMACEUTICS (2009)

Review Physiology

Estrogen receptors:: How do they signal and what are their targets

Nina Heldring et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Multidisciplinary Sciences

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Sitarina Widyarini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Dermatology

Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein

Sitarina Widyarini et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)

Article Environmental Sciences

Urinary phytoestrogen concentrations in the U. S. population (1999-2000)

L Valentín-Blasini et al.

JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY (2005)

Article Agriculture, Multidisciplinary

Plant foods and herbal sources of resveratrol

J Burns et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)

Review Medicine, General & Internal

Mechanisms of disease - Production and actions of estrogens

CJ Gruber et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)