Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/ijms222111654
Keywords
Alzheimer's disease; drug delivery; drug targeting; neurodegenerative diseases; Parkinson's disease
Funding
- European Union (FEDER funds)
- National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) [PT2020 UID/MULTI/04378/2013-POCI/01/0145/FEDER/007728]
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Nanomedicine has the potential to treat neurological diseases by modifying nanoparticles to cross the blood-brain barrier and target the brain tissue directly.
The blood-brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the brain and target the desired anatomic region. The use of nanomedicine has great potential to overcome this problem, since one can modify nanoparticles with strategic molecules that can interact with the BBB and induce uptake through the brain endothelial cells and consequently reach the brain tissue. This review addresses the potential of nanomedicines to treat neurological diseases by using nanoparticles specially developed to cross the BBB.
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