Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms221910704
Keywords
angiogenesis; trophic factor; ribonuclease; cell proliferation; protein; mimicking peptides; copper complexes
Funding
- Italian ministry of Education, Universities and Research (MIUR) [2017WBZFHL]
- ERA-NET Cofund M-ERA-NET 2 call [4274]
- University of Catania (PIAno di inCEntivi per la RIcerca di Ateneo 2020/2022 CHANCE_Linea di Intervento 1 e GRABIO_Linea di intervento 2), Beneficentia Stiftung, Vaduz [BEN2019/48]
- University of Pisa [PRA_2020_58]
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Angiogenesis is crucial in the wound healing process, with angiogenin and copper playing significant roles in regulating the formation of new blood vessel pathways. Understanding the interaction between these factors could pave the way for developing new drugs for chronic non-healing wounds.
Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.
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