Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms221910867
Keywords
skeletal muscles; trauma; muscle healing and repair; stem cells; macrophages; immune cell role in tissue repair
Funding
- Translational Medicine at Dept. of medicine, Surgery and Dentistry, University of Salerno
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The article summarizes the repair of skeletal muscle tissue structure and functionality through the involvement of multiple cell types in severe muscle injury, such as muscle stem cells and peripheral blood mononucleate cells. It describes the potential effects of peripheral cell infusions as a new therapy for muscle healing and their impact on immune responses.
In severe muscle injury, skeletal muscle tissue structure and functionality can be repaired through the involvement of several cell types, such as muscle stem cells, and innate immune responses. However, the exact mechanisms behind muscle tissue regeneration, homeostasis, and plasticity are still under investigation, and the discovery of pathways and cell types involved in muscle repair can open the way for novel therapeutic approaches, such as cell-based therapies involving stem cells and peripheral blood mononucleate cells. Indeed, peripheral cell infusions are a new therapy for muscle healing, likely because autologous peripheral blood infusion at the site of injury might enhance innate immune responses, especially those driven by macrophages. In this review, we summarize current knowledge on functions of stem cells and macrophages in skeletal muscle repairs and their roles as components of a promising cell-based therapies for muscle repair and regeneration.
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