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Anti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins
Anja Kovanda et al.
SCIENTIFIC REPORTS (2015)
SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice
Elisabeth Dirren et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)
Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers
Axel Freischmidt et al.
BRAIN (2014)
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
Johnathan Cooper-Knock et al.
BRAIN (2014)
Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
Hong Chen et al.
CELL STEM CELL (2014)
Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells
Stefania Marcuzzo et al.
EXPERIMENTAL NEUROLOGY (2014)
Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis
Hongyan Wang et al.
HUMAN MOLECULAR GENETICS (2014)
The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex
Isabelle N. King et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Increased Expression of MicroRNA-29a in ALS Mice: Functional Analysis of Its Inhibition
Katie Nolan et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2014)
Genetic counselling in ALS: facts, uncertainties and clinical suggestions
Adriano Chio et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)
Direct Binding of Ataxin-2 to Distinct Elements in 3′ UTRs Promotes mRNA Stability and Protein Expression
Moe Yokoshi et al.
MOLECULAR CELL (2014)
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Aaron R. Haeusler et al.
NATURE (2014)
Detecting and characterizing circular RNAs
William R. Jeck et al.
NATURE BIOTECHNOLOGY (2014)
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
Sami J. Barmada et al.
NATURE CHEMICAL BIOLOGY (2014)
The phenotypic variability of amyotrophic lateral sclerosis
Bart Swinnen et al.
NATURE REVIEWS NEUROLOGY (2014)
miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients
Bruna De Felice et al.
NEUROGENETICS (2014)
Analysis of Novel NEFL mRNA Targeting microRNAs in Amyotrophic Lateral Sclerosis
Muhammad Ishtiaq et al.
PLOS ONE (2014)
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
Gregorio Valdez et al.
PLOS ONE (2014)
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Sarah Mizielinska et al.
SCIENCE (2014)
An ALS-associated mutation in the FUS 3′-UTR disrupts a microRNA-FUS regulatory circuitry
Stefano Dini Modigliani et al.
NATURE COMMUNICATIONS (2014)
Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis
Koichi Wakabayashi et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci
Sarah Mizielinska et al.
ACTA NEUROPATHOLOGICA (2013)
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS
Tania F. Gendron et al.
ACTA NEUROPATHOLOGICA (2013)
Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression
Gaelle Bruneteau et al.
BRAIN (2013)
lincRNAs: Genomics, Evolution, and Mechanisms
Igor Ulitsky et al.
CELL (2013)
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila
Zhaodong Li et al.
HUMAN MOLECULAR GENETICS (2013)
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
J. Gavin Daigle et al.
HUMAN MOLECULAR GENETICS (2013)
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Erica D. Koval et al.
HUMAN MOLECULAR GENETICS (2013)
Calcium Channel Agonists Protect against Neuromuscular Dysfunction in a Genetic Model of TDP-43 Mutation in ALS
Gary A. B. Armstrong et al.
JOURNAL OF NEUROSCIENCE (2013)
Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration
Dorothee Dormann et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
Shi-Yan Ng et al.
MOLECULAR CELL (2013)
TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation
Valerio Di Carlo et al.
MOLECULAR NEUROBIOLOGY (2013)
The changing scene of amyotrophic lateral sclerosis
Wim Robberecht et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
Aaron P. Russell et al.
NEUROBIOLOGY OF DISEASE (2013)
Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature
A. Chio et al.
NEUROEPIDEMIOLOGY (2013)
Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
Peter E. A. Ash et al.
NEURON (2013)
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
Christopher J. Donnelly et al.
NEURON (2013)
Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations
Zhijun Zhang et al.
PLOS ONE (2013)
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
Tao Zu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Clotilde Lagier-Tourenne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
Eveline S. Arnold et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction
Lucas M. Bronicki et al.
RNA (2013)
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Kohji Mori et al.
SCIENCE (2013)
Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
C. Parisi et al.
CELL DEATH & DISEASE (2013)
Mechanisms of RNA-induced toxicity in CAG repeat disorders
R. Nalavade et al.
CELL DEATH & DISEASE (2013)
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Youn-Bok Lee et al.
CELL REPORTS (2013)
Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels
Danae Campos-Melo et al.
MOLECULAR BRAIN (2013)
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis
Yoshinori Nishimoto et al.
MOLECULAR BRAIN (2013)
A Complex Network of MicroRNAs Expressed in Brain and Genes Associated with Amyotrophic Lateral Sclerosis
Santosh Shinde et al.
INTERNATIONAL JOURNAL OF GENOMICS (2013)
Incidence of Amyotrophic Lateral Sclerosis Among American Indians and Alaska Natives
Paul H. Gordon et al.
JAMA NEUROLOGY (2013)
Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
Axel Freischmidt et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)
Examples of sequence conservation analyses capture a subset of mouse long non-coding RNAs sharing homology with fish conserved genomic elements
Swaraj Basu et al.
BMC BIOINFORMATICS (2013)
Role of PGC-1 alpha signaling in skeletal muscle health and disease
Chounghun Kang et al.
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER (2012)
Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
Johnathan Cooper-Knock et al.
BRAIN (2012)
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Margaret S. Ebert et al.
CELL (2012)
FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment
Mariangela Morlando et al.
EMBO JOURNAL (2012)
Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles
Takao Naganuma et al.
EMBO JOURNAL (2012)
A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
Bruna De Felice et al.
GENE (2012)
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
Thomas Derrien et al.
GENOME RESEARCH (2012)
TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells
Claudia Colombrita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
Elisa Majounie et al.
LANCET NEUROLOGY (2012)
Landscape of transcription in human cells
Sarah Djebali et al.
NATURE (2012)
An integrated encyclopedia of DNA elements in the human genome
Ian Dunham et al.
NATURE (2012)
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
Clotilde Lagier-Tourenne et al.
NATURE NEUROSCIENCE (2012)
Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype
Nicola J. Rutherford et al.
NEUROBIOLOGY OF AGING (2012)
Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons
Takuto Hideyama et al.
NEUROBIOLOGY OF DISEASE (2012)
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Julia Salzman et al.
PLOS ONE (2012)
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
Yukio Kawahara et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Faisal Fecto et al.
ARCHIVES OF NEUROLOGY (2011)
Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution
Igor Ulitsky et al.
CELL (2011)
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
Moran N. Cabili et al.
GENES & DEVELOPMENT (2011)
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
Chantelle F. Sephton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study
Adriano Chio et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)
Vimentin intermediate filaments modulate the motility of mitochondria
Oxana E. Nekrasova et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
Energy metabolism in amyotrophic lateral sclerosis
Luc Dupuis et al.
LANCET NEUROLOGY (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Magdalini Polymenidou et al.
NATURE NEUROSCIENCE (2011)
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
James R. Tollervey et al.
NATURE NEUROSCIENCE (2011)
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
Peter M. Andersen et al.
NATURE REVIEWS NEUROLOGY (2011)
RNA targets of wild-type and mutant FET family proteins
Jessica I. Hoell et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
Glial Cells in Amyotrophic Lateral Sclerosis
Jurate Lasiene et al.
NEUROLOGY RESEARCH INTERNATIONAL (2011)
Nuclear factor TDP-43 can affect selected microRNA levels
Emanuele Buratti et al.
FEBS JOURNAL (2010)
Incidence of amyotrophic lateral sclerosis in Europe
Giancarlo Logroscino et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
Michael J. Strong
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
Andrew C. Elden et al.
NATURE (2010)
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
Shuo-Chien Ling et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
miRNA malfunction causes spinal motor neuron disease
Sharon Haramati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Prognostic factors in ALS: A critical review
Adriano Chio et al.
AMYOTROPHIC LATERAL SCLEROSIS (2009)
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
Fabian Feiguin et al.
FEBS LETTERS (2009)
Amyotrophic Lateral Sclerosis-linked Mutant SOD1 Sequesters Hu Antigen R (HuR) and TIA-1-related Protein (TIAR) IMPLICATIONS FOR IMPAIRED POST-TRANSCRIPTIONAL REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR
Liang Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Latent Cluster Analysis of ALS Phenotypes Identifies Prognostically Differing Groups
Jeban Ganesalingam et al.
PLOS ONE (2009)
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
Andrew H. Williams et al.
SCIENCE (2009)
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
T. J. Kwiatkowski et al.
SCIENCE (2009)
Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain
Jasmina Ponjavic et al.
PLOS GENETICS (2009)
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
Xiangting Wang et al.
NATURE (2008)
Specific expression of long noncoding RNAs in the mouse brain
Tim R. Mercer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression
Liang Lu et al.
JOURNAL OF NEUROSCIENCE (2007)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
Mutational analysis of the Cu/Zn superoxide dismutase gene in a Catalan ALS population:: Should all sporadic ALS cases also be screened for SOD1?
Josep Gamez et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
MJ Greenway et al.
NATURE GENETICS (2006)
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Piera Pasinelli et al.
NATURE REVIEWS NEUROSCIENCE (2006)
TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines
R Fujii et al.
JOURNAL OF CELL SCIENCE (2005)
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
R Fujii et al.
CURRENT BIOLOGY (2005)
The Microprocessor complex mediates the genesis of microRNAs
RI Gregory et al.
NATURE (2004)
Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002
MR Turner et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2003)
Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis
FM Menzies et al.
JOURNAL OF NEUROCHEMISTRY (2002)
El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
BR Brooks et al.
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2000)