Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms222212139
Keywords
2-mercapto-benzimidazole; sulfonic derivatives; heterocyclic thiosemicarbazides; tuberculostatic activity
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The research focused on the impact of acyl-thiosemicarbazide residue reaction extension on the structure of 5-nitrobenzimidazole, aiming to enhance the applicative potential of new thiosemicarbazide derivatives in biochemistry and confirming the tuberculostatic activity of three compounds against Mycobacterium tuberculosis through in vitro biological tests.
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and H-1 NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.
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