4.7 Article

Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging

Aida Muntsant et al.

Summary: The study reveals that life expectancy decreases with aging, with females having a worse healthy life expectancy. The bidirectional interactions between cardiovascular diseases and Alzheimer's disease are promising areas for further research.

BIOMEDICINES (2021)

Article Biochemistry & Molecular Biology

Specific Phospholipid Modulation by Muscarinic Signaling in a Rat Lesion Model of Alzheimer's Disease

Alberto Llorente-Ovejero et al.

Summary: The study demonstrates that the loss of BFCN results in alterations of lipid species related to Ch metabolism at NMB and cortical projection areas, along with changes in mAChR activity in the brain. These findings suggest that targeting specific lipid metabolic pathways could be a potential therapeutic strategy for improving cholinergic neurotransmission and preserving cell membrane integrity in AD.

ACS CHEMICAL NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Deconstructing Alzheimer's Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Anais Vignon et al.

Summary: Alzheimer's disease is a common form of dementia with no cure available. Research focuses on the molecular mechanisms of AD to find better models to replicate the pathology. The aim is to help researchers identify the most relevant disease models to advance the field.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease

Ceren Emre et al.

Summary: This study investigated lipid and cytokine profiles, glial activation, and inflammatory proteins in an APP knock-in AD mouse model. It found age-specific changes in the brain lipidome, with increased pro-inflammatory and pro-resolving lipid mediators only in older age groups despite early Aβ pathology. Additionally, alterations in phospholipids signaled early pathological changes in membrane composition.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Survival Bias and Crosstalk between Chronological and Behavioral Age: Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging

Lydia Gimenez-Llort et al.

Summary: New evidence suggests a high degree of heterogeneity in clinical and temporal patterns in normal and Alzheimer's disease (AD) patients, with increased mortality and the need for specific end-of-life prognosticators. In a study involving 915 mice, it was found that male APP23 mice had better survival curves than females, allowing for the characterization of behavioral signatures in middle-aged, old, and long-lived male animals. Different behavioral features were observed in male APP23 mice compared to controls, especially in coping with stress, thigmotaxis, frailty, gait, and cognition, showing age- and genotype-dependent non-linear behavioral signatures in long-lived animals.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies

Luiz Henrique Medeiros Geraldo et al.

Summary: Lysophosphatidic acid (LPA) is a versatile bioactive phospholipid that can signal through specific receptors to have diverse effects in central nervous system development and angiogenesis, as well as acting as a potent mediator in neuropathic pain, neurodegenerative diseases, and cancer progression. Understanding the production and signaling mechanisms of LPA is crucial for comprehending its biological functions in the central nervous system in both health and disease states.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Cell Biology

Caveolin: A New Link Between Diabetes and AD

Andrei Surguchov

CELLULAR AND MOLECULAR NEUROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Masaru Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Neurosciences

Endocannabinoid and Muscarinic Signaling Crosstalk in the 3xTg-AD Mouse Model of Alzheimer's Disease

Alberto Llorente-Ovejero et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Biochemistry & Molecular Biology

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Ji-Na Kong et al.

JOURNAL OF LIPID RESEARCH (2018)

Article Biochemistry & Molecular Biology

Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease

E. Gonzalez de San Roman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

Review Pharmacology & Pharmacy

Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems

Luke M. Healy et al.

CURRENT DRUG TARGETS (2016)

Article Multidisciplinary Sciences

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease

Nurgul Aytan et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Manuel Torres et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

Article Clinical Neurology

In vivo type 1 cannabinoid receptor availability in Alzheimer's disease

Rawaha Ahmad et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2014)

Article Neurosciences

Type-1 Cannabinoid Receptor Activity During Alzheimer's Disease Progression

Ivan Manuel et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Article Biochemical Research Methods

Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease

Raul Gonzalez-Dominguez et al.

JOURNAL OF PROTEOMICS (2014)

Article Biochemistry & Molecular Biology

Plasma phospholipids identify antecedent memory impairment in older adults

Mark Mapstone et al.

NATURE MEDICINE (2014)

Article Geriatrics & Gerontology

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

Luke Whiley et al.

NEUROBIOLOGY OF AGING (2014)

Article Neurosciences

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis

Timothy A. Couttas et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Lysophospholipids and their receptors in the central nervous system

Ji Woong Choi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Article Biochemistry & Molecular Biology

Lysophosphatidic acid induces increased BACE1 expression and A beta formation

Jing Shi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Review Pharmacology & Pharmacy

Chemical Probes of Endocannabinoid Metabolism

Jacqueline L. Blankman et al.

PHARMACOLOGICAL REVIEWS (2013)

Article Biochemistry & Molecular Biology

Autotaxin protects microglial cells against oxidative stress

Rana Awada et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Neurosciences

CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice

Ester Aso et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Neurosciences

Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease

Stephen C. Cunnane et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Biochemistry & Molecular Biology

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

Robin B. Chan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

Giuseppe Astarita et al.

PLOS ONE (2011)

Article Psychiatry

Metabolome in progression to Alzheimer's disease

M. Oresic et al.

TRANSLATIONAL PSYCHIATRY (2011)

Review Biochemistry & Molecular Biology

S1P metabolism in cancer and other pathological conditions

Weng In Leong et al.

BIOCHIMIE (2010)

Article Geriatrics & Gerontology

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

Hua Cheng et al.

NEUROBIOLOGY OF AGING (2010)

Article Biochemistry & Molecular Biology

Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex

Jasinda H. Lee et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Article Biochemistry & Molecular Biology

Reduced Membrane Lipids in the Cortex of Alzheimer's Disease Transgenic Mice

Jeffrey K. Yao et al.

NEUROCHEMICAL RESEARCH (2009)

Review Biochemistry & Molecular Biology

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

Istvan Katona et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1)

Shinya Shano et al.

NEUROCHEMISTRY INTERNATIONAL (2008)

Article Neurosciences

Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients

Ken Umemura et al.

NEUROSCIENCE LETTERS (2006)

Article Multidisciplinary Sciences

The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins

JE Lauckner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Immunology

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Jared Ehrhart et al.

JOURNAL OF NEUROINFLAMMATION (2005)

Article Multidisciplinary Sciences

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

G Marsicano et al.

SCIENCE (2003)

Article Developmental Biology

Microglial activation state and lysophospholipid acid receptor expression

CS Tham et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2003)

Article Geriatrics & Gerontology

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

S Oddo et al.

NEUROBIOLOGY OF AGING (2003)

Review Neurosciences

Inflammation in neurodegenerative disease - A double-edged sword

T Wyss-Coray et al.

NEURON (2002)

Article Endocrinology & Metabolism

A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures

N Blondeau et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)

Review Biochemistry & Molecular Biology

Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3

CL Sayas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)

Article Neurosciences

Involvement of CB1 cannabinoid receptors in emotional behaviour

M Martin et al.

PSYCHOPHARMACOLOGY (2002)

Article Biochemistry & Molecular Biology

Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells

T Möller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Multidisciplinary Sciences

Neuroscience: Breaking down scientific barriers to the study of brain and mind

ER Kandel et al.

SCIENCE (2000)

Review Developmental Biology

Essential fatty acids and the brain: possible health implications

KA Youdim et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2000)