Related references
Note: Only part of the references are listed.
Review
Biochemistry & Molecular Biology
Petra A. Tsuji et al.
Summary: Selenium is an essential element in the diet and has many health benefits, such as preventing heart disease and cancer, supporting male reproduction, and boosting the immune system. It plays important roles in the molecular biology of organisms and its incorporation into proteins is a unique feature. Research has focused on selenium's role in cancer prevention and its potential involvement in various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sabrina Sales Martinez et al.
Summary: Viral infections continue to impact human health despite advancements in scientific knowledge, and the COVID-19 pandemic has highlighted the importance of nutritional strategies to maintain a healthy immune system. Selenium, an essential trace element, has been found to reduce the occurrence and severity of viral infections. Its benefits are mainly attributed to its incorporation into selenocysteine, a crucial component of proteins. Studies suggest that selenium deficiency alters immune response and increases oxidative stress, leading to higher pathogenicity and damage in viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Olivia M. Guillin et al.
Summary: The study demonstrated that selenium deficiency in HIV infection affects CD4 T-cell count and lifespan, while selenoproteins play a crucial role in antioxidant defense and redox balance. Selenium interacts with HIV infection in various cellular models, showing slight effects on virus production and infectivity, but reducing the percentage of infected cells slightly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Didac Santesmasses et al.
Summary: Selenium is incorporated into selenoproteins as the 21st amino acid selenocysteine (Sec). There are 25 selenoproteins encoded in the human genome, and their synthesis requires a dedicated machinery. Most selenoproteins are oxidoreductases with important functions in human health. Deficiencies in selenoproteins can lead to various disorders, with mutations in selenoprotein genes or Sec machinery genes being common causes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qian Sun et al.
Summary: Selenium, an essential trace element, is crucial for the biosynthesis of selenoproteins, but autoimmunity to SELENOP can impair selenium transport and affect the synthesis of protective enzymes like GPX3. This suggests that autoimmune response to SELENOP should be considered as an additional biomarker for assessing selenium deficiency health risks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lenny K. Hong et al.
Summary: SELENOF is a selenoprotein involved in prostate cancer, with polymorphisms in the 3'-UTR region affecting the risk of prostate cancer mortality in African American men. Low levels of SELENOF in prostate cancer tissues may contribute to tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Atsuki Shimizu et al.
Summary: The study revealed that the thioredoxin system from Pseudomonas stutzeri specifically reduces selenite in the presence of TrxA (PsTrxA), with Cys33 and Cys36 residues being crucial for selenite reduction via the formation of PsTrxA-SeO intermediate. The results also suggest the importance of TrxA in selenoprotein biosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhan-Ling Liang et al.
Summary: ZIP8 is a crucial transmembrane protein responsible for transporting essential micronutrients and heavy metals, including selenium. The relationship between ZIP8 mutations, cellular selenium transportation, and human diseases has not been fully explored. Research shows that ZIP8 plays a role in modulating cellular selenium levels and may have potential implications for disease prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chi Ma et al.
Summary: The selenoprotein family comprises 25 members, with SELENOI being a unique member functioning as an ethanolamine phosphotransferase. SELENOI plays a crucial role in the synthesis of cellular membrane constituents, impacting metabolic reprogramming and proliferative capacity in T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyunwoo Kang et al.
Summary: SELENOW and Trx1 play important roles in cellular processes, regulating redox processes and survival mechanisms by interacting with 14-3-3 proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Theresa Wolfram et al.
Summary: The study shows that selenium can regulate the redox signaling in macrophages, affecting the expression of selenoproteins and the production of lipid mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Briana K. Shimada et al.
Summary: Selenium is an essential trace element crucial for cardiovascular health through its incorporation into selenoproteins, which are key to maintaining proper cardiovascular function. Deficiency in selenium can lead to various cardiovascular diseases, and selenium may potentially serve as a complementary therapy for prevention or treatment of cardiovascular disease by interacting with microRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jessica A. Canter et al.
Summary: The study suggests that Selenof may play a significant role in the development of colon tumors, affecting intestinal barrier integrity and the structural changes in glandular and mucin-producing goblet cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Noelia Fradejas-Villar et al.
Summary: Transfer RNA ([Ser]Sec) modification plays a crucial role in selenoprotein expression. Mutations in TRIT1 and tRNA([Ser]Sec) have different effects on selenoprotein levels and UGA/Sec read-through. The lack of isopentenylation of tRNA([Ser]Sec) affects UGA/Sec read-through, but differs from an A37G mutation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jisu Jung et al.
Summary: SEPHS1 deficiency in endothelial cells leads to the accumulation of superoxide and lipid peroxide, along with a reduction in nitric oxide levels, ultimately resulting in cell dysfunction through DNA damage and inhibition of cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Paul R. Copeland et al.
Summary: This passage discusses the decoding of genetic information into polypeptides during translation, as well as the reassignment of UGA codons in selenoprotein mRNAs to encode for selenocysteine. It also examines the fate of ribosomes that fail to incorporate selenocysteine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniel J. Torres et al.
Summary: Selenium plays a crucial role in hypothalamic physiology by supporting leptin signaling and maintaining proper redox balance. Knockout mice of the selenocysteine tRNA gene showed less weight gain on a high-fat diet, with female mice retaining hypothalamic sensitivity to leptin while males were unaffected, indicating a sexually dimorphic influence of selenium on neurobiology and energy homeostasis. These findings provide new insights into the impact of selenoproteins on a specific population of hypothalamic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Erik Schoenmakers et al.
Summary: Selenium, an essential trace element for human health, is incorporated into selenoproteins through the amino acid selenocysteine. Mutations in genes essential for selenocysteine incorporation pathway can result in systemic selenoprotein deficiency, leading to a complex disorder affecting specific tissues and impairing antioxidant and stress defense mechanisms. Antioxidant therapy shows promise in ameliorating oxidative damage, but the long-term benefits are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jordan Sonet et al.
Summary: Selenoproteins, which contain the rare amino acid selenocysteine with selenium atom, play crucial roles in cell homeostasis, antioxidant defense, and cell signaling in mammals. The expression of the selenoproteome, comprised of 25 selenoprotein genes, is tightly regulated by the selenium status of the body. The study presents an alternative strategy for characterizing selenoproteome regulation using radioactive Se-75 isotope and non-radioactive selenium isotopes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lutz Schomburg
Summary: Selenium is an essential trace element in the human diet, and deficiency can increase health risks, especially during pregnancy, severe illness, or COVID-19. Decline in selenium status can lead to impaired immune response and increased risk of autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jeyoung Bang et al.
Summary: SEPHS1 deficiency causes a gradual increase in oxidative stress, which alters signaling pathways during gastrulation and ultimately leads to apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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