CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space

CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines involved in the development of many inflammatory diseases. It activates CXCR2 and, at high levels, CXCR1. The expression of CXCL1 is elevated in inflammatory reactions and also has important functions in physiology, including the induction of angiogenesis and recruitment of neutrophils. Due to a lack of reviews that precisely describe the regulation of CXCL1 expression and function, in this paper, we present the mechanisms of CXCL1 expression regulation with a special focus on cancer. We concentrate on the regulation of CXCL1 expression through the regulation of CXCL1 transcription and mRNA stability, including the involvement of NF-kappa B, p53, the effect of miRNAs and cytokines such as IFN-gamma, IL-1 beta, IL-17, TGF-beta and TNF-alpha. We also describe the mechanisms regulating CXCL1 activity in the extracellular space, including proteolytic processing, CXCL1 dimerization and the influence of the ACKR1/DARC receptor on CXCL1 localization. Finally, we explain the role of CXCL1 in cancer and possible therapeutic approaches directed against this chemokine.

Automated summary

CXCL1 is an important chemokine involved in the development of inflammatory diseases. Its expression is elevated in inflammatory reactions and it plays important roles in physiology. This paper presents the mechanisms of CXCL1 expression regulation with a focus on cancer, including transcription regulation, mRNA stability, and activity regulation in the extracellular space. The role of CXCL1 in cancer and potential therapeutic approaches are also discussed.