Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms23010460
Keywords
thyroid cancer; mitophagy; mitochondrial DNA mutation; mitochondrial dynamics; apoptosis
Funding
- Russian Science Foundation [20-15-00337]
- Russian Science Foundation [20-15-00337] Funding Source: Russian Science Foundation
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This paper discusses the relationship between the etiology of thyroid cancer and mitochondrial function, and explores the use of known drugs and induction of mitochondria-mediated apoptosis as a new direction in anti-thyroid cancer therapy.
Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria-primarily, the regulation of mitochondria-mediated apoptosis, Ca2+ homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.
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