Journal
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
Volume 17, Issue 2, Pages -Publisher
ESG
DOI: 10.20964/2022.02.14
Keywords
Hybridization chain reaction; electrochemical biosensor; nanomaterials; signal amplification
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Funding
- Hunan Provincial Natural Science Foundation of China [2019JJ70038]
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This review highlights the progress of HCR-based electrochemical biosensors in different types of signal reporters, which have advantages of simplicity, enzyme-free, and isothermal amplification.
With the bloom of DNA nanotechnology, diverse DNA amplification strategies have been designed and applied in bioassays. Among them, hybridization chain reaction (HCR) is prevalent because of its advantages of simplicity, enzyme-free and isothermal amplification. HCR-based electrochemical biosensors have been widely used in broad fields of food safety, environmental monitor and disease diagnosis. This review highlights the progress in HCR-based electrochemical biosensors which are divided based on the types of signal reporters.
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