Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 18, Issue 4, Pages 1695-1705Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.64982
Keywords
amino acid metabolism; ferroptosis; cancer; combinatorial therapy
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Funding
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYGD18005]
- Sichuan Provincial Department of Science and Technology [2019YJ0056]
- National Natural Science Foundation of China [82073059]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [81621003]
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This manuscript systematically summarizes the latest advances of amino acid metabolism in regulating ferroptosis and discusses the potential combination of therapeutic strategies that simultaneously target amino acid metabolism and ferroptosis in cancer to eliminate tumors or limit their invasiveness.
Ferroptosis, a new form of programmed necrosis characterized by iron-dependent lethal accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting amino acid (AA) availability can selectively suppress tumor growth and has been a promising therapeutic strategy for cancer therapy. Compelling studies have indicated that AA metabolism is also involved in ferroptosis, closely regulating its initiation and execution. This manuscript systematically summarizes the latest advances of AA metabolism in regulating ferroptosis and discusses the potential combination of therapeutic strategies that simultaneously target AA metabolism and ferroptosis in cancer to eliminate tumors or limit their invasiveness.
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