Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 18, Issue 3, Pages 1211-1219Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.67529
Keywords
Key words; replication initiation factors; cancer stem cell; stemness; drug resistance
Categories
Funding
- National Natural Science Foundation of China [82173365]
- Natural Science Basic Research Project of Shaanxi Province [2020JM-362]
- Key projects of Natural Science Foundation of Shaanxi Province [2021JZ-36]
- Institutional foundation of The First Affiliated Hospital of Xi'an Jiaotong University [2019ZYTS-19, 2020QN-05]
- Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University, China [XJTU1AF-CRF-2017-007]
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Replication licensing factors play a crucial role in regulating DNA replication and may be involved in the occurrence and development of cancer, as well as impacting the resistance of cancer cells to chemotherapy.
The replication licensing factors strictly regulate the DNA replication origin licensing process to guarantee the stability of the genome. Numerous experimental studies have recently demonstrated that the replication licensing factors as oncogenes are essential for the occurrence and development of cancers. Drug resistance, being one of the main characteristics of cancer stem cells, can cause a high recurrence rate and a low survival rate in patients with different cancers. However, the function of the replication licensing factors in cancer stemness remains unclear. The following article highlights the most recent research on DNA replication origin licensing factors in cancer and their function in anti-cancer drug resistance. Moreover, this article proposes a new perspective that replication licensing factors as chemotherapy shield affect anti-cancer drug resistance by promoting the stemness of cancer cells.
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