Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 205, Issue -, Pages 520-529Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.02.012
Keywords
Alginate; Tempo-oxidized cellulose nanofibrils; Polydopamine nanoparticles
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)
- Ministry of Health and Welfare, Republic of Korea [HI14C3484]
- National Research Foundation (NRF)
- Korean government (MSIT) [NRF-2019M3A9E2066348, 2021M3H4A4079292]
- Korea Health Promotion Institute [HR14C0008070022] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2021M3H4A4079292] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Bioprinting is an emerging technology for manufacturing cell-laden 3D scaffolds to support cell growth and differentiation. This study formulated various nanocomposite hydrogel-based bioinks using natural and biocompatible biomaterials and found that a bioink containing 1.5% alginate and 1.5% TOCNF, with or without 0.5% PDANP, demonstrated suitable printability for 3D printing and induced significant osteogenesis in vitro.
Bioprinting is an emerging technology for manufacturing cell-laden three-dimensional (3D) scaffolds, which are used to fabricate complex 3D constructs and provide specific microenvironments for supporting cell growth and differentiation. The development of bioinks with appropriate printability and specific bioactivities is crucial for bioprinting and tissue engineering applications, including bone tissue regeneration. Therefore, to produce functional bioinks for osteoblast printing and bone tissue formation, we formulated various nanocomposite hydrogel-based bioinks using natural and biocompatible biomaterials (i.e., alginate, tempo-oxidized cellulose nanofibrils (TOCNF), and polydopamine nanoparticles (PDANPs)). Rheological studies and printability tests revealed that bioinks containing 1.5% alginate and 1.5% TOCNF in the presence or absence of PDANP (0.5%) are suitable for 3D printing. Furthermore, in vitro studies of 3D-printed osteoblast-laden scaffolds indicated that the 0.5% PDANP-incorporated bioink induced significant osteogenesis. Overall, the bioink consisting of alginate, TOCNF, and PDANPs exhibited excellent printability and bioactivity (i.e., osteogenesis).
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