Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 196, Issue -, Pages 46-53Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.12.062
Keywords
Spirulina platensis; Polysaccharide; Immunostimulatory
Funding
- National Key Research and Development Program of China [2018YFC0311202]
- Pro-gram of Department of Natural Resources of Guangdong Province [[2020] 038, [2020] 036]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Key-Area Research and Development Program of Guangdong Province [2020B1111030004]
- National Natural Science Foundation of Guangdong, China [2018A030313626]
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In this study, a novel heteropolysaccharide called SP90-1 with immunostimulatory and antitumor activity was discovered from Spirulina platensis. The study found that SP90-1 significantly enhanced the phagocytic capacity of cells, promoted the secretion of certain substances, and remarkably inhibited the growth of certain tumor cells.
In this study, a novel heteropolysaccharide named SP90-1 with immunostimulatory and antitumor activity was purified and characterized from Spirulina platensis. SP90-1 has a molecular weight of 63.92 kDa and mainly consists of rhamnose (Rha), glucose (Glc), galactose (Gal) and glucuronic acid (GlcA), followed by the minor components Fuc and Xyl. The backbone of SP90-1 was determined to be -> 2)-alpha-D-Rhap-(1 ->& nbsp;2,3)-alpha-D-Rhap-(1 & nbsp;-> 4)-beta-D-Glcp-(1 & nbsp;-> [3)-beta-D-Rhap-(1 ->](3), with branches at the O-3 of Rha, consisting of the side chains 4-Galp and 4GlcpA. SP90-1 was found to significantly enhance phagocytic capacity, promote the secretion of nitric oxide (NO), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells, and remarkably inhibit the growth of A549 lung cancer cells. These findings demonstrate that SP90-1 could potentially be further explored for immunomodulatory biomedical applications.
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