4.7 Article

Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidaseenzyme along with in silico study

Munther Alomari et al.

Summary: A series of 19 indole-based-thiadiazole derivatives were synthesized and tested for alpha-glucosidase inhibition. Some compounds showed high inhibitory potential, with structure activity relationships established based on phenyl ring substitutions. Molecular docking study confirmed binding interactions of the most active compounds, while kinetic study revealed them to be non-competitive inhibitors.

BIOORGANIC CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies

Muhammad Mansha et al.

Summary: An enhanced acetylcholinesterase (AChE) activity is a hallmark in early stages of Alzheimer's disease, leading to decreased acetylcholine (ACh) levels and cholinergic dysfunction. New fluoroquinolone derivatives were synthesized and evaluated for AChE and BChE inhibitory activities, with the compound 7g showing the highest activity. Compounds with electronegative functions at the ortho position of the phenyl group exhibited higher activities, with molecular docking studies revealing conventional H-bonding interactions with active residues.

ARABIAN JOURNAL OF CHEMISTRY (2021)

Article Multidisciplinary Sciences

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor

Muhammad Taha et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against β-glucuronidase and their interactions thereof

Muhammad Taha et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

2,5-Disubstituted thiadiazoles as potent β-glucuronidase inhibitors; Synthesis, in vitro and in silico studies

Muhammad Taha et al.

BIOORGANIC CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives

Muhammad Taha et al.

BMC CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives

Muhammad Taha et al.

BIOORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors

Muhammad Taha et al.

BIOORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives

Muhammad Taha et al.

BIOORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Synthesis, molecular docking study and thymidine phosphorylase inhibitory activity of 3-formylcoumarin derivatives

Muhammad Taha et al.

BIOORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Synthesis of alpha amylase inhibitors based on privileged indole scaffold

Tayyaba Noreen et al.

BIOORGANIC CHEMISTRY (2017)

Review Chemistry, Medicinal

A review on recent developments of indole-containing antiviral agents

Ming-Zhi Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling

Hamidreza Akrami et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Chemistry, Medicinal

Synthesis of indole-2-hydrazones in search of potential leishmanicidal agents

Muhammad Taha et al.

MEDICINAL CHEMISTRY RESEARCH (2014)

Article Chemistry, Medicinal

Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors

Alicja Skrzypek et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

Jonah Cheung et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Selective Butyrylcholinesterase Inhibitors Using Polyphenol-polyphenol Hybrid Molecules

Yeun Ji Woo et al.

BULLETIN OF THE KOREAN CHEMICAL SOCIETY (2011)

Article Biochemistry & Molecular Biology

How the cholinesterases got their modern names

Victor P. Whittaker

CHEMICO-BIOLOGICAL INTERACTIONS (2010)

Article Biochemistry & Molecular Biology

Synthesis of bis-Schiff bases of isatins and their antiglycation activity

Khalid Mohammed Khan et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives

Mohammad Yusuf et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

Review Chemistry, Medicinal

Multi-target-directed ligands to combat neurodegenerative diseases

Andrea Cavalli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Chemistry, Medicinal

A new class of anti-MRSA and anti-VRE agents: Preparation and antibacterial activities of indole-containing compounds

Yasuo Yamamoto et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Review Pharmacology & Pharmacy

Targeting acetylcholinesterase to treat neurodegeneration

Ulrike Holzgrabe et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2007)

Article Multidisciplinary Sciences

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

NH Greig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Chemistry, Medicinal

Synthesis of substituted indole derivatives as a new class of antimalarial agents

A Agarwal et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Chemistry, Medicinal

Recent progress in the development of coumarin derivatives as potent anti-HIV agents

DL Yu et al.

MEDICINAL RESEARCH REVIEWS (2003)

Article Biochemistry & Molecular Biology

Cholinesterases: New roles in brain function and in Alzheimer's disease

E Giacobini

NEUROCHEMICAL RESEARCH (2003)

Review Neurosciences

Neurobiology of butyrylcholinesterase

S Darvesh et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Review Clinical Neurology

Alzheimer disease as a vascular disorder - Nosological evidence

JC de la Torre

STROKE (2002)

Article Medicine, Research & Experimental

Butyrylcholinesterase activity and risk factors for coronary artery disease

VM Alcantara et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2002)

Article Agriculture, Multidisciplinary

Use of cholinesterase activity in monitoring organophosphate pesticide exposure of cattle produced in tropical areas

VT Pardío et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)