4.7 Article

Potential therapeutic interventions of plant-derived isoflavones against acute lung injury

Journal

INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 101, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.intimp.2021.108204

Keywords

Acute lung injury; Anti-inflammatory; Immunomodulatory; Phytoestrogens; Signaling pathway

Funding

  1. Ministry of Science and Education of the Russian Federation [FEUZ-2020-0058 (H687.42B.223/20)]
  2. Science & Engineering Research Board (SERB) Department of Science & Technology, Government of India [EMR/2017/000973]

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Isoflavones, as natural compounds, have potential anti-inflammatory and antioxidant effects in the treatment of ALI and can positively impact the disease through multiple pathways. While research scope is limited, there is potential to fill gaps in understanding the protective roles of isoflavones in ALI, especially in terms of antioxidant potential, inhibition of inflammatory pathways, and associated molecular mechanisms.
Acute lung injury (ALI) is a life-threatening syndrome that possibly leads to high morbidity and mortality as no therapy exists. Several natural ingredients with negligible adverse effects have recently been investigated to possibly inhibit the inflammatory pathways associated with ALI at the molecular level. Isoflavones, as phytoestrogenic compounds, are naturally occurring bioactive compounds that represent the most abundant category of plant polyphenols (Leguminosae family). A broad range of therapeutic activities of isoflavones, including antioxidants, chemopreventive, anti-inflammatory, antiallergic and antibacterial potentials, have been extensively documented in the literature. Our review exclusively focuses on the possible anti-inflammatory, antioxidant role of botanicals'-derived isoflavones against ALI and their immunomodulatory effect in experimentally induced ALI. Despite the limited scope covering their molecular mechanisms, isoflavones substantially contributed to protecting from ALI via inhibiting toll-like receptor 4 (TLR4)/Myd88/NF-0B pathway and subsequent cytokines, chemokines, and adherent proteins. Nonetheless, future research is suggested to fill the gap in elucidating the protective roles of isoflavones to alleviate ALI concerning antioxidant potentials, inhibition of the inflammatory pathways, and associated molecular mechanisms.

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