Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 101, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2021.108179
Keywords
Osteoclasts; Osteoblasts; Chondrocytes; Immune cells; Crosstalk
Categories
Funding
- National Natural Science Foundation of China [81800785, 81972085]
- Natural Science Foundation of Guangdong Province [2018A0303100027, 2021A1515010706]
- Guangdong Provincial Key Clinical Discipline-Orthopedics [2000005]
- Sanming Project of Shenzhen Health and Family Planning Commission [SZSM201612086]
- Shenzhen Science and Technology Planning [JCYJ20180228163401333, JCYJ20190806170612680]
- Shenzhen Key Medical Discipline Construction Fund [SZXK025]
- discipline construction Capacity Improvement project of Shenzhen Municipal Health Commission [SZXJ2018065]
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Osteoimmunology studies the interactions between the immune system and the skeletal system, with different immune cells playing various roles in regulating osteoclasts and chondrocytes. These cells maintain a dynamic balance through multiple signaling mechanisms.
The term osteoimmunology was coined to denote the bridge between the immune system and the skeletal system. Osteoimmunology is interdisciplinary, and a full understanding and development of this bridge will provide an in-depth understanding of the switch between body health and disease development. B lymphocytes can promote the maturation and differentiation of osteoclasts, and osteoclasts have a negative feedback effect on B lymphocytes. Different subtypes of T lymphocytes regulate osteoclasts in different directions. T lymphocytes have a two-way regulatory effect on osteoblasts, while B lymphocytes have minimal regulatory effects on osteoblasts. In contrast, osteoblasts can promote the differentiation and maturation of T lymphocytes and B lymphocytes. Different immune cells have different effects on chondrocytes; some cooperate with each other, while some antagonize each other. In a healthy adult body, bone resorption and bone formation are in a dynamic balance under the action of multiple mechanisms. In this review, we summarize the interactions and key signaling molecular mechanisms between each type of cell in the immune system and the skeletal system.
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