4.7 Article

Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1a/NLPR3 pathway

Related references

Note: Only part of the references are listed.
Review Immunology

The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

Ruixiang Chen et al.

Summary: Chronic pain negatively affects patients' quality of life, and the dysregulation of NLRP3 inflammasome may contribute to the pathogenesis of chronic pain. Successful therapeutic approaches targeting NLRP3 inflammasome have been developed for chronic pain treatment.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Biochemistry & Molecular Biology

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

Jing-Yiing Wu et al.

MOLECULAR CELL (2020)

Article Immunology

Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation

Qing Yu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Oncology

Inflammation, Cancer and Immunity-Implication of TRPV1 Channel

Joanna Katarzyna Bujak et al.

FRONTIERS IN ONCOLOGY (2019)

Article Integrative & Complementary Medicine

Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway

Huan Chen et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Review Immunology

Pain and immunity: implications for host defence

Pankaj Baral et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

Yi Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Review Immunology

Immune Cytokines and Their Receptors in Inflammatory Pain

Andrew D. Cook et al.

TRENDS IN IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

Michael P. Murphy et al.

Article Immunology

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

C. Guo et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain

Andrea Bedini et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Review Rheumatology

Inflammation in gout: mechanisms and therapeutic targets

Alexander K. So et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Review Immunology

TRPs and pain

Yi Dai

SEMINARS IN IMMUNOPATHOLOGY (2016)

Article Immunology

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

Amanda Littlewood-Evans et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Review Rheumatology

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

Ursula Fearon et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Neurosciences

Naringenin reduces inflammatory pain in mice

Felipe A. Pinho-Ribeiro et al.

NEUROPHARMACOLOGY (2016)

Review Immunology

NLRP3 at the interface of metabolism and inflammation

Moritz Haneklaus et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Rheumatology

Role of HIF-1α and HIF-2α in osteoarthritis

Fang-Jie Zhang et al.

JOINT BONE SPINE (2015)

Article Neurosciences

Pirt contributes to uterine contraction-induced pain in mice

Changming Wang et al.

MOLECULAR PAIN (2015)

Review Cell Biology

Succinate: a metabolic signal inflammation

Evanna Mills et al.

TRENDS IN CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Naeha Subramanian et al.

Article Multidisciplinary Sciences

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill et al.

NATURE (2013)

Article Rheumatology

Effect and Treatment of Chronic Pain in Inflammatory Arthritis

Yvonne C. Lee

CURRENT RHEUMATOLOGY REPORTS (2013)

Article Biochemistry & Molecular Biology

TRPV1-lineage neurons are required for thermal sensation

Santosh K. Mishra et al.

EMBO JOURNAL (2011)

Review Pharmacology & Pharmacy

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels

Joris Vriens et al.

MOLECULAR PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1

Andrew Y. Kim et al.