Oromandibular parafunction in chronic graft-versus-host disease: novel association and treatment approach

Chronic graft-versus-host disease (cGVHD) complicating allogeneic haemopoietic stem cell transplantation rarely involves the nervous system; oromandibular parafunction has not been previously reported. We describe five patients with cGVHD, presenting with bruxism, limitation of mouth opening, jaw locking, pain and masseter hypertrophy. Pathophysiological mechanisms are discussed. Targeted botulinum toxin injections were an effective treatment with minimal side-effects.

Automated summary

The article describes five patients with cGVHD presenting with oromandibular parafunction, discussing the pathophysiological mechanisms and the efficacy of targeted botulinum toxin injections with minimal side effects.