Journal
INTERNAL MEDICINE
Volume 61, Issue 7, Pages 1063-1065Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.7902-21
Keywords
Lambert-Eaton myasthenic syndrome (LEMS); treatment algorithm; electrophysiological examination; 3; 4-diaminopyridine; cholinesterase inhibitors
Categories
Funding
- Health and Labour Sciences Research Grants for research on intractable diseases (Neuroimmunological Disease Research Committee) from the Ministry of Health, Labor and Welfare of Japan
Ask authors/readers for more resources
We report two LEMS patients who responded dramatically to cholinesterase inhibitors. Cholinesterase inhibitors were effective in improving gait disturbance and autonomic symptoms in LEMS patients.
We herein report two P/Q-type voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS) patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When symptomatic treatment was started with pyridostigmine, gait disturbance was ameliorated, and his modified Rankin scale decreased from 4 points to 3 points. Patient 2, a 68-year-old man, had cancer-free LEMS. Distigmine bromide was very effective and ameliorated not only his gait disturbance but also autonomic symptoms, and his modified Rankin scale decreased from 2 points to 1 point. Cholinesterase inhibitors alone may be effective in a small portion of LEMS patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available