Sarcoid-like Granulomatous Lung Disease with Subacute Progression in Silicosis

A 67-year-old man was admitted to our hospital with cough and fatigue. He had had long-term exposure to silica due to cement processing. Chest computed tomography showed bilateral centrilobular nodules, and hilar and mediastinal lymphadenopathy with calcification, suggesting chronic silicosis. Within a few months, these nodules enlarged, and bilateral patchy consolidations appeared. A lung biopsy revealed sarcoid-like granulomas with birefringent particles under polarized light without malignancy or infection. He was diagnosed with silicosis-associated sarcoid-like granulomatous lung disease, rather than sarcoidosis, according to the clinicopathological findings. His pulmonary manifestations improved after the discontinuation of silica exposure and combination therapy of corticosteroid and azathioprine.

Automated summary

This article reports a case of silicosis-associated sarcoid-like granulomatous lung disease, rather than sarcoidosis, in a patient with long-term exposure to silica. The patient's pulmonary manifestations improved after discontinuation of silica exposure and combination therapy.