Journal
INTERNAL MEDICINE
Volume 61, Issue 3, Pages 281-290Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.8424-21
Keywords
glycemic variability; time in range; continuous glucose monitoring; diabetic microvascular complications; diabetic macrovascular complications
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The goal of diabetes treatment is to maintain good glycemic control, prevent the development and progression of diabetic complications. Glycemic variability (GV) is recognized as an important index of glycemic control and is closely associated with diabetic vascular complications.
The goal of diabetes treatment is to maintain good glycemic control, prevent the development and progression of diabetic complications, and ensure the same quality of life and life expectancy as healthy people. Hemoglobin A1c (HbA1c) is used as an index of glycemic control, but strict glycemic control using HbA1c as an index may lead to severe hypoglycemia and cardiovascular death. Glycemic variability (GV), such as excessive hyperglycemia and hypoglycemia, is associated with diabetic vascular complications and has been recognized as an important index of glycemic control. Here, we reviewed the definition and evaluated the clinical usefulness of GV, and its relationship with diabetic complications and therapeutic strategies to reduce GV.
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