Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 134, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.inoche.2021.109026
Keywords
Cu2+; Hydrazone; Lysosome; Naphthalimide; Fluorescent probe; Pyrrole
Categories
Funding
- National Natural Science Foundation of China [21907023, 21001040]
- Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province [U1304202, U1604124]
- Science and Technology Department of Henan Province [212102210033, 202102310228, 212102210646, 212102310099]
- Education Department of Henan Province [19A150001]
- Key Program of Xuchang [2019-JC-02]
- Fundamental Research Funds for the Universities of Henan Province [NSFRF210343, NSFRF180323]
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A fluorescence-enhanced probe based on Schiff-based condensation reaction was developed for selective detection of Cu2+. The distinct recognition mechanism was investigated through mass spectra, H-1 NMR studies, and DFT calculations. Imaging and costaining experiments confirmed the successful visualization of lysosomal Cu2+ by the probe.
In this study, we developed a fluorescence-enhanced probe (1) based on a simple Schiff-based condensation reaction for Cu2+ selection. We investigated its distinct recognition mechanism through mass spectra, H-1 NMR studies, and DFT calculations. The imaging and costaining experiments indicated that the probe could successfully image lysosomal Cu2+.
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