Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 133, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.inoche.2021.108946
Keywords
Complex; Apoptosis; Molecular docking; DNA
Categories
Funding
- Natural Science Foun-dation of China [U1608224, 21171118]
- Distinguished Professor Project of Liaoning province
- Liao Ning Revitalization Talents Program [XLYC1907047]
- Liaoning Science and Technology Project Management [2019-BS-192]
- Basic Research Project of Educational Department of Liaoning Province [LQ2020005, LQ2020004]
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A new metal-organic complex, Mn(L)2.4H2O, has been successfully synthesized and shows potential significance for cancer treatment. The complex exhibits good binding ability with DNA and can effectively act on cancer cells.
A new metal-organic complex (MOC), Mn(L)2.4H2O is successfully designed and synthesized by 2-(1,2,4-Triazol1-yl)-4-picolinic acid ligand and Mn(NO3)2.4H2O in the mixed solvent of methanol and water. The complex was characterized by single-crystal X-ray diffraction, element analysis, Powder X-ray diffraction(PXRD). The binding constant between complex and DNA is 9.3 x 104, indicating that the complex and fish sperm DNA can bind well. Viscosity experiments prove that the complex interacts with DNA in an intercalation mode. Apoptosis and inverted microscope experiments show that the complex has obvious apoptotic effects on cancer cells. In general, the synthesized Mn(II) complex is of great significance to the treatment of cancer.
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