Synthesis of a Lanthanide Metal-Organic Framework and Its Fluorescent Detection for Phosphate Group-Based Molecules Such as Adenosine Triphosphate

Adenosine triphosphate (ATP) is an important kind of metabolized biological molecule that is formed in organisms, especially in mitochondria, is used universally as energy, and is one of the most significant multifunctional biological molecules. Metal-organic frameworks (MOFs) have been widely used in many applications such as gas storage and separation, drug delivery, heterogeneous catalysis, chemical sensors, etc. Remarkably, lanthanide MOFs (Ln-MOFs), which display large pores, multiple dimensions, and unique lanthanide luminescence properties, are widely used as chemical sensors. A novel three-dimensional probe, Eu-2(sbdc)(3)(H2O)(3) (Eu-sbdc), was successfully self-assembled with Eu(NO3)(3)center dot 6H(2)O and 5,5-dioxo-5H-dibenzo[b,d]thiophene-3,7-dicarboxylic acid (H(2)sbdc). The Ln-MOF Eu-sbdc can quickly and effectively optically detect ATP via a luminescent quenching mechanism. The K-sv value of Eu-sbdc is 1.02 x 10(4) M-1, and the lower detection limit of Eu-sbdc for ATP is 20 mu M, which is more sensitive to ATP. Its mechanism of monitoring ATP might be a dynamic or static quenching process. Eu-sbdc could effectively and quickly recognize ATP with high sensitivity.

Automated summary

Adenosine triphosphate (ATP) is an important biological molecule used universally as energy. Lanthanide metal-organic frameworks (Ln-MOFs) have unique properties and are widely used as chemical sensors. Eu-sbdc, a novel three-dimensional probe, can effectively detect ATP through a luminescent quenching mechanism.