Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 158, Issue 4, Pages 537-543Publisher
SPRINGER
DOI: 10.1007/s10517-015-2803-2
Keywords
multipotent mesenchymal stromal cells; umbilical cord; fibroblasts; fetal liver; surface markers
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Funding
- Russian Research Foundation [14-15-00648]
- Russian Science Foundation [14-15-00648] Funding Source: Russian Science Foundation
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Expression of 20 surface markers was analyzed in cultures of mesenchymal stromal cells of the umbilical cord, fibroblasts from adult and fetal human skin, and fi broblast-like cells of fetal liver was analyzed by fl ow cytometry. The studied cultures did not express hemopoietic cells markers, but were positive for CD73, CD90, and CD105 markers recommended by the International Society of Cell Therapy for the identifi cation of the multipotent mesenchymal stromal cells. Fetal liver fi broblast-like cells were positive for CD54; this marker was absent in skin fi broblast cultures, but was expressed by umbilical cord mesenchymal stromal cells. Further study of these cells revealed a minor subpopulation of cells co-expressing CD24 and CD90 or CD24 and CD54. We hypothesized that these cells probably participate in epithelial mesenchymal transition.
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