Journal
INFECTION GENETICS AND EVOLUTION
Volume 97, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2021.105166
Keywords
Tuberculosis; Cytokine storm; Immune response and IL-6
Categories
Funding
- National Natural Science Foundation [81871182, 81371851]
- National key RD plan [2016YFC0502304]
- Fundamental Research Funds for the Central Universities [XDJK2017D101, XDJK2017D100, XDJK2017D099]
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Tuberculosis is one of the oldest diseases in humanity, with complications and mortality often associated with cytokine storms. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis. Researching new therapeutic approaches to block IL-6 signaling is currently a focus in tuberculosis research.
Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or subsequent death emerging from these infections are frequently connected with cytokine storm. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis. Therefore, there is a need to research some new therapeutic approaches to block IL-6 signaling that are right now being applied to the M. tuberculosis. In this review, we investigate the implication of IL-6 in the context of tuberculosis research.
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