Clinical outcomes in patients infected with different SARS-CoV-2 variants at one hospital during three phases of the COVID-19 epidemic in Marseille, France

Editorial Material Medicine, General & Internal

Genetic Variants of SARS-CoV-2-What Do They Mean?

Adam S. Lauring et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

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Article Medicine, General & Internal

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Robert Challen et al.

Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Infectious Diseases

Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage

Philippe Colson et al.

Summary: Genomic surveillance of SARS-CoV-2 led to the identification of a new spike 501Y variant, with amino acid substitutions found in genomes from patients diagnosed in early 2021. Further investigation into the spread, epidemiology, and clinical impact of this variant is warranted.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Infectious Diseases

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February

Daniel J. Grint et al.

Summary: The SARS-CoV-2 B.1.1.7 VOC is spreading across Europe and poses a higher risk of death compared to non-VOC cases, with increased mortality in older individuals and those with comorbidities. This variant has the potential to spread faster and cause higher mortality than previous strains.

EUROSURVEILLANCE (2021)

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Article Infectious Diseases

Emergence and outcomes of the SARS-CoV-2 'Marseille-4' variant

Pierre-Edouard Fournier et al.

Summary: In Marseille, France, a second wave of SARS-CoV-2 epidemic occurred from June, with the Marseille-4 variant being the major cause, carrying 13 hallmark mutations including one affecting the receptor binding domain of the spike protein. This variant has caused 2106 infections since September 2020 and is associated with a higher proportion of hypoxemia.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Letter Virology

Implementation of an in-house real-time reverse transcription-PCR assay to detect the emerging SARS-CoV-2 N501Y variants

Marielle Bedotto et al.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Article Infectious Diseases

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

Dan Frampton et al.

Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.

LANCET INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Nicholas G. Davies et al.

Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.

NATURE (2021)

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Letter Infectious Diseases

Does SARS-CoV-2 re-infection depend on virus variant?

Philippe Gautret et al.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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News Item Multidisciplinary Sciences

THE MUTATION THAT HELPS DELTA SPREAD LIKE WILDFIRE

Ewen Callaway

NATURE (2021)

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Letter Public, Environmental & Occupational Health

SARS-CoV-2 variant from India to Marseille: The still active role of ports in the introduction of epidemics

Bernard La Scola et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2021)

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Review Genetics & Heredity

COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern

Md. Zeyaullah et al.

Summary: The COVID-19 outbreak originated in Wuhan, China and quickly spread globally, challenging the current global health system. The virus displays high infectivity and pathogenicity, similar to common cold symptoms, with limited treatment options. Researchers are now focusing on monitoring viral variants and their impact on vaccine efficacy.

FRONTIERS IN GENETICS (2021)

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Review Medicine, General & Internal

SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence

Thi Loi Dao et al.

Summary: Viral mutations, such as the D614G variant, may lead to increased infectivity, while evidence of their association with disease severity is limited, with some mutations associated with milder infections. Some variants are more common in patients from countries with high fatality rates, but their relation to the severity of COVID-19 infection remains unclear.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, Research & Experimental

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review

SeyedAhmad SeyedAlinaghi et al.

Summary: Researchers have identified three main genomic variants of SARS-CoV-2, including type A, type B, and type C, as well as three clades, S, V, and G. Studies show that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent mutations globally. The common D614G amino acid change has become prevalent since December 2019, and deleterious mutations in genes like N and Orf3a have been linked to patients' mortality. Overall, these variants have altered the clinical manifestations of COVID-19, leading to increased transmissibility, morbidity, and mortality, highlighting the importance of considering them in pandemic interventions.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology