Journal
INDUSTRIAL CROPS AND PRODUCTS
Volume 176, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.indcrop.2021.114328
Keywords
Alpinia coriandriodora D; Fang; Essential oil; Chemical composition; Proliferation; Apoptosis; Migration and invasion
Categories
Funding
- Guizhou Science and Technology Program, China [Qian Ke He Zhi Cheng (2020) 1Y133, Ji Chu-ZK (2021) Yiban 150, (2021) Yiban 520]
- Guizhou University Introduced Talent Research Project, China [Gui Da Ren Ji He Zi (2019) 29]
Ask authors/readers for more resources
Alpinia coriandriodora rhizome essential oil showed promising anticancer properties in vitro by inducing cell cycle arrest and apoptosis, as well as inhibiting cell migration and invasion abilities. Further in vivo studies are encouraged to explore its potential as a natural anticancer drug.
Alpinia coriandriodora is widely cultivated as a medicinal and edible Zingiberaceae plant in Guangxi, China. Since essential oils from Zingiberaceae plants can be used as a potential source of anticancer drugs, this study was designed to identify the chemical composition of A. coriandriodora rhizome essential oil (EO) and firstly elucidate its anticancer activities and related mechanisms. The GC-FID/MS results indicated that the most predominant component of EO was (E)-2-decenal (56.3%). Based on the MTT results, EO exhibited comparable cytotoxicity to A549 cells and lower cytotoxicity to non-cancerous cells compared with the positive control (elemene injection). For related mechanism studies, EO inhibited the A549 cells proliferation, resulting from inducing cell cycle arrest at G1 phase via downregulation of cyclin E2-CDK2 and cyclin D3-CDK4/CDK6 complexes and upregulation of p21. Meanwhile, it induced the apoptosis through mitochondrial pathway with the successive enhancement in the Bax/Bcl-2 ratio, Delta psi m decline, cyt c release, activation of caspase-9 and caspase-3, and PARP cleavage. Moreover, it inhibited the migration and invasion ability of A549 cells via downregulation of MMP-2 and Ncadherin, as well as upregulation of E-cadherin. Hence, EO has outstanding anticancer properties in vitro, and this fact encourages further studies using in vivo models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available