Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 159, Issue 6, Pages 782-785Publisher
SPRINGER
DOI: 10.1007/s10517-015-3075-6
Keywords
induced pulmonary adenomas; gonadectomy; neonatal androgenization; sex-related differences in urethane sensitivity
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Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone after urethane injection caused virtually no changes in urethane effect in males and females. By contrast, elevation of testosterone concentrations in newborn male and female mice by injections or its decrease in feminized males receiving sodium glutamate during the neonatal period reduced the sensitivity to the carcinogenic effect of urethane in adult males and to its increase in females.
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