Journal
IMMUNOTHERAPY
Volume 14, Issue 1, Pages 41-64Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2021-0103
Keywords
adoptive cell therapy; cancer vaccines; checkpoint inhibitors; gastric cancer; immunotherapy; microsatellite instability; tumor mutational burden
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Gastric cancer is the fifth most common cancer worldwide and immunotherapy has attracted considerable attention as a potential treatment option, with ongoing clinical trials to assess its efficacy in treating gastric cancer.
Gastric cancer, the fifth most frequent cancer and the fourth leading cause of cancer deaths, accounts for a devastating death rate worldwide. Since the majority of patients with gastric cancer are diagnosed at advanced stages, they are not suitable for surgery and present with locally advanced or metastatic disease. Recent advances in immunotherapy have elicited a considerable amount of attention as viable therapeutic options for several cancer types. This work presents a summary of the currently ongoing clinical trials and critically addresses the efficacy of a large spectrum of immunotherapy approaches in the general population for gastric cancer as well as in relation to tumor genetic profiling.
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