4.6 Article

MicroRNA-590-3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice

Journal

IMMUNOLOGY
Volume 165, Issue 2, Pages 260-273

Publisher

WILEY
DOI: 10.1111/imm.13434

Keywords

apoptosis; autophagy; miR-590-3p; systemic lupus erythematosus; T helper 17 cells

Categories

Funding

  1. Medical Guide Project from the Science and Technology Commission of Shanghai Municipality (CN) [20ZR1411500, 19411962500]
  2. National Natural Science Foundation of China [82073436, 81871277]
  3. Outstanding Youth Medical Talents of Shanghai Rising Stars of Medical Talent Youth Development Program
  4. Zhuoxue Plan of Fudan University

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Inhibition of T helper 17 cells through upregulation of miR-590-3p reduces inflammation in autoimmune diseases like SLE. Our study shows that miR-590-3p promotes apoptosis in Th17 cells by inhibiting autophagy, offering a promising therapeutic strategy for SLE.
T helper 17 (Th17) cells have a pathogenic effect in many autoimmune diseases. Inhibition of Th17 cells can alleviate the inflammatory damage in autoimmune diseases. Our previous study found that microRNA-590-3p (miR-590-3p) was involved in the differentiation of Th17 cells in systemic lupus erythematosus (SLE). Here, we demonstrated that an increase in Th17 cells was correlated with low expression of miR-590-3p in patients with SLE and in lupus mice. Upregulation of miR-590-3p reduced the differentiation and promoted apoptosis of Th17 cells. Subsequent experiments demonstrated that miR-590-3p promoted apoptosis in Th17 cells by inhibiting autophagy. Autophagy-related 7 (Atg7) was the direct target of miR-590-3p that blocked the autophagy pathway. Finally, treatment of MRL/lpr mice with miR-590-3p agomir ameliorated lupus nephritis and skin lesions. Our work revealed that miR-590-3p inhibited Th17 cells by suppressing autophagy and that increased miR-590-3p expression was able to ameliorate the clinical symptoms of lupus. Therefore, miR-590-3p may be a promising therapeutic target for SLE and other Th17 cell-dependent autoimmune diseases.

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