T peripheral helper cells in autoimmune diseases

Pathologic T cell-B cell interactions underlie many autoimmune diseases. The T cells that help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical features of T follicular helper cells, such as expression of CXCR5 and BCL6. A population of PD-1(hi) CXCR5(-) T peripheral helper (Tph) cells has now been recognized in multiple autoantibody-associated diseases. Tph cells display a distinctive set of features, merging the ability to provide B cell help with the capacity to migrate to inflamed peripheral tissues. Here, we review the scope of immune-related conditions in which Tph cells have been implicated and provide a perspective on their potential contributions to pathologic B cell activation in autoimmune diseases. We discuss Tph cells as a promising therapeutic strategy in autoimmunity and consider the utility of tracking Tph cells in blood as a biomarker to quantify aberrant T cell-B cell activation in patients with autoimmune diseases.

Automated summary

Pathologic T cell-B cell interactions play a crucial role in autoimmune diseases. Tph cells, a unique subset of T cells, have been identified in autoantibody-associated diseases, providing both B cell help and the ability to migrate to inflamed peripheral tissues. Understanding and tracking Tph cells are crucial for studying the pathogenesis and therapeutic strategies of autoimmune diseases.