Journal
IMMUNITY
Volume 55, Issue 2, Pages 201-209Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2022.01.014
Keywords
-
Categories
Funding
- Garfield Weston foundation
- Swedish Research council [2021-06529]
- Karolinska Institutet
- Bure Equity AB
- Jonas & Christina af Jochnick Foundation
- Swedish Research Council [2021-06529] Funding Source: Swedish Research Council
Ask authors/readers for more resources
SARS-CoV-2 infections in children usually result in mild or asymptomatic infections, and the reasons behind this are not fully understood. Possible explanations include more efficient local tissue responses, better thymic function, and crossreactive immunity. Post-infectious hyperinflammatory syndromes are rare in children and young people, but very rarely seen in adults. This article offers an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people from a life history and energy allocation perspective.
SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and crossreactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available