Microglia: Immune and non-immune functions

As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease. They are aided in their tasks by intricate bidirectional communication with other brain cells under steady-state conditions as well as with infiltrating peripheral immune cells during perturbations. Harmonious cell-cell communication involvingmicroglia are considered crucial tomaintain the healthy state of the tissue environment and to overcome pathology such as neuroinflammation. Analyses of such intercellular pathways have contributed to our understanding of the heterogeneous but context-associated microglial responses to environmental cues across neuropathology, including inflammatory conditions such as infections and autoimmunity, as well as immunosuppressive states as seen in brain tumors. Here, we summarize the latest evidence demonstrating how these interactions drive microglia immune and non-immune functions, which coordinate the transition from homeostatic to disease-related cellular states.

Automated summary

Microglia, as resident macrophages of the CNS, play crucial roles in maintaining brain homeostasis and responding to disease, through intricate bidirectional communication with other brain cells and infiltrating peripheral immune cells. This harmonious cell-cell communication is essential for maintaining tissue health and overcoming pathology such as neuroinflammation.